肿瘤干细胞在头颈部鳞状细胞癌诊断及治疗中的应用前景  

Application prospects of the current findings on cancer stem cells derived from head and neck squamous cell carcinoma

作　　者：贾国栋[1,2] 张萍[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院口腔颌面外科,上海市口腔医学重点实验室,上海200011 [2]上海交通大学附属第一人民医院松江分院口腔科,上海201600

出　　处：《中国实用口腔科杂志》2012年第12期709-713,共5页Chinese Journal of Practical Stomatology

基　　金：国家自然科学基金(81272978);国家自然科学基金(30772433)

摘　　要：头颈部鳞状细胞癌(head and neck squamous cell carcinoma,HNSCC)是全球第六大常见的癌症,随着各项分子生物学和细胞生物学技术的不断发展,针对HNSCC的各种诊断和治疗方法也在不断进步,但近30年来HNSCC患者的生存率并未明显提高。有学者提出肿瘤干细胞学说,认为肿瘤内部存在一小群具有干细胞样特性的细胞,称为肿瘤干细胞。研究表明,它是肿瘤的起源,也是造成肿瘤复发、转移、放化疗耐受的关键因素。因此,深入研究这群肿瘤干细胞的生物学特性,寻找有效的治疗靶点,对于肿瘤的最终治愈具有重要的生物学价值及临床应用前景。本文主要就目前HNSCC肿瘤干细胞相关研究进展的临床应用前景做一综述。Head and neck squamous cell carcinoma （HN- SCC） is the sixth most common cancer worldwide. Despite great advances in diagnostic and therapeutic methods, the 5-year survival rate of patients suffering with HNSCC remains unchanged over the last 30 years due to treatment failure and distant metastases of tumor. Increasing evidences demonstrate that the growth and spread of cancer is driven by a small subpopulation of cancer cells, defined as cancer stem cells （CSCs）. Recent data indicate that the initiation, growth, recurrence and metastasis of cancers are distinctive features of the small population of CSCs with sternness properties. Deep investigation of the behavior of these CSCs is of importance in identifying target therapy methods and improving patients＇ prognosis. In this review, we focus on some recent progresses of HNSCC derived CSCs which may be of great benefit to the future diagnosis and therapy of HNSCC.

关 键 词：头颈鳞状细胞癌 肿瘤干细胞 预后 治疗耐 受 靶向治疗 

分 类 号：R78[医药卫生—口腔医学]