养血清脑颗粒中有效成分的肠外翻吸收研究  

Absorption of Active Ingredients in Yangxue Qingnao Granule in Rat Everted Gut Scas

作　　者：陈晓鹏[1,2] 李昂[2] 褚扬[2] 张兰兰[2] 周水平[2] 朱永宏[2] 刘昌孝[1,3] 

机构地区：[1]天津大学化工学院,天津300072 [2]天津天士力制药集团股份有限公司,天津300410 [3]天津药物研究院释药技术与药代动力学国家重点实验室,天津300193

出　　处：《中国实验方剂学杂志》2013年第4期159-162,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家"重大新药创制"科技重大专项(2013ZX09402-202)

摘　　要：目的:研究养血清脑颗粒中2种主要有效成分芍药苷和阿魏酸在大鼠不同肠段的肠外翻模型中的吸收动力学特征。方法:采用大鼠肠外翻模型,高效液相色谱法测定含量,计算养血清脑颗粒中芍药苷和阿魏酸的吸收参数,分析其在不同部位的吸收特征。结果:养血清脑颗粒中芍药苷和阿魏酸在各肠段均为线性吸收,相关系数的平方(R2)均达到0.9以上,符合零级吸收速率。肠道不同部位的吸收实验表明,其最佳吸收部位为回肠。结论:养血清脑颗粒中芍药苷和阿魏酸在肠道不同部位吸收均符合零级吸收速率。Objective： The everted gut seas in vitro was used to investigate intestinal absorption kinetics characteristics of paeoniflorin and ferulic acid from Yangxue Qingnao granule at different intestinal section. Method ： In vitro everted gut model was applied. The absorption concentration of paeoniflorin and ferulic acid, was detected by HPLC, and the absorption parameter was calculated for describing the absorption characters. Resul~： The absorption of paeoniflorin and ferulic acid was linearity in different intestine, and the square of coefficient correlation exceed 0.9, which consistent with zero order rate process. The absorption of paeoniflorin and ferulie acid in ileum was quick. Conclusion： The absorption of paeoniflorin and ferulie acid in Yangxue Qingnao granule conforms to the zero order rate process at different sections of intestine.

关 键 词：养血清脑颗粒 芍药苷 阿魏酸 肠外翻 高效液相色谱 

分 类 号：R284.1[医药卫生—中药学]