NF-κB、c-myc在成人喉乳头状瘤中的表达及意义  

The expression and significance of NF-κB and c-myc in adult papilloma of laryngx

作　　者：蒋正举[1] 刘兆辉[1] 张春林[1] 刘华庆[2] 吴兴龙[2] 杨永福[2] 

机构地区：[1]遵义医学院附属医院耳鼻咽喉科,563003 [2]遵义医学院附属医院病理科,563003

出　　处：《贵州医药》2012年第8期686-688,共3页Guizhou Medical Journal

基　　金：遵义医学院附属医院中青年科研项目启动基金资助[院字(2008)17号]

摘　　要：目的探讨NF-κB和c-myc在成人喉乳头状瘤中的表达及意义。方法收集2001年3月至2007年3月间病理检查确诊为喉乳头状瘤的患者标本54例,免疫组化技术检测NF-κB和c-myc在喉乳头状瘤中的表达情况,并根据有无非典型增生及非典型增生分度进行亚组分析;正常喉黏膜组织15例作为对照组。结果NF-κB和c-myc在成人喉乳头状瘤中表达增高,与正常组织相比差异具有统计学意义(P<0.05)。在成人喉乳头状瘤患者亚组分组中,随着非典型增生的程度增加,NF-κB和c-myc表达的阳性率以及强度相应增加(P<0.05)。结论NF-κB和c-myc均有可能参与成人喉乳头状瘤的发生发展及恶变,可作为预测成人喉乳头状瘤患者临床结局的候选分子。Objective To investigate the expression and significance of NF-κB and c-myc in adult papilloma of laryngx. Methods Collected the 54 cases specimens which were adult papilloma of laryngx from March in 2001 to March in 2007. Total of 69 cases of paraffin section with immunoperoxidase staining method was used to detect the distribution of NF-κB and c-myc in 15 cases of laryngeal normal epithelial tissue, 54 cases of laryngeal papilloma. Results Compared with laryngeal normal epithelial tis- sue, there were differences in statistical significance the distribution of NF-gB and c-myc increased in laryngeal papilloma （P〈0.05）. As severe atypical hyperplasia degree increased in laryngeal papillo- ma, the distribution of NF-κB andc-myc increased gradually. Conclusion The NF-gB, c-myc may play a key role in laryngeal papillomgs malignant change.

关 键 词：NF-ΚB C-MYC 喉乳头状瘤 免疫组化 

分 类 号：R739.65[医药卫生—肿瘤]