肝硬化门脉高压性胃病相关因素分析  

Analysis of portal hypertensive gastropathy related factors in liver cirrhosis

作　　者：毛华[1] 李瑞[1] 

机构地区：[1]南方医科大学珠江医院,广州市510282

出　　处：《实用医学杂志》2013年第4期595-597,共3页The Journal of Practical Medicine

基　　金：广东省科技厅科技计划项目(编号:2009B030801212)

摘　　要：目的:探讨肝硬化门脉高压性胃病(portal hypertensive gastropathy,PHG)与肝功能、食管-胃底静脉曲张分级及其他相关因素的关系。方法:胃镜观察已确诊的107例肝硬化患者胃黏膜病变及食管-胃底静脉曲张程度,测定血清胆红素、白蛋白、凝血酶原时间、肌酐及腹水量,肝功能进行Child-Pugh及MELD分级,数据进行统计学分析。结果:PHG内镜表现以马赛克征、蛇皮样病变、猩红热样疹最为常见,多位于胃底及胃体,其发生与食管静脉曲张程度、肝功损害程度及酒精、胆汁等刺激性因素有关,与胃底静脉曲张无相关性。结论:肝硬化PHG内镜特征明显,门脉高压是PHG形成的必备条件,同时也有其他损伤因素的参与。Objective To investigate the relationships between portal hypertensive gastropathy （PHG） and liver function, grades of gastroesophageal varices and other related risk factors in liver cirrhosis. Methods The lesion of gastric mucosa and degree of gastroesophageal varices of 107 patients with liver cirrhosis were observed by endoscopy. Serum bilirubin, albumin, prothrombin time, creatinine and ascites volume were measured. Liver functions were classified according to Child-Pugh and MELD. Results Mosaic-like pattern lesions, snake＇s skin lesion and scarlatiniform rash were the most common endoscopic features in PHG,and often located in the gastric fundus and body, which were correlated with the grade of esophageal varices, severity of liver dysfunction and excitant factors like alcohol and bile, while not correlated with gastric fundus variees. Conclusions Endoscopic features were obvious of PHG in liver cirrhosis.Portal hypertension was the necessary condition in the formation of PHG, and other damage factors were also involved.

关 键 词：肝硬化 门脉高压性胃病 食管-胃底静脉曲张 

分 类 号：R575.2[医药卫生—消化系统]