牙周炎骨丧失机制中关于炎症和解偶联的研究  

Study of inflammation and uncoupling in mechanisms of periodontal bone loss

作　　者：张晓敏[1] 郭恪[1] 任春霞[1] 闫嘉晴[1] 林崇韬[1] 

机构地区：[1]吉林大学口腔医院牙周病科,长春130021

出　　处：《国际口腔医学杂志》2013年第2期206-208,共3页International Journal of Stomatology

摘　　要：炎症和骨丧失是细菌感染性疾病牙周炎的两大特征。近年来,人们通过对其相关性的研究,诞生了一门新的学科———骨骼免疫学,为更好地研究牙周炎的发病机制提供了一个方向。由炎症引发宿主免疫反应进而导致牙槽骨丧失涉及到很多方面,炎症不仅刺激破骨细胞形成,而且干扰骨形成和骨吸收的偶联过程。炎症的发生部位和持续时间都对骨丧失产生了一定的作用。本文将就牙周炎骨丧失机制的新进展作一综述。Periodontal disease is characterized by both inflammation and bone loss. Advances in research in the intimate relationship of them have resulted in a new field of science called osteoimmunology and provides a context for better understanding the pathogenesis of periodontitis. There are several aspects of the immuno-inflammatory host response that ultimately results in loss of alveolar bone. Periodontal inflammation not only stimulates osteoclastogenesis, but also interferes with the uncoupling of bone formation and bone resorption. Furthermore, arguments suggest a critical role of the spatial and temporal aspects of inflammation in the periodontium. This review is about the new progress of bone loss＇s mechanism in periodontitis.

关 键 词：牙周炎 骨形成 骨吸收 

分 类 号：R781.44[医药卫生—口腔医学]