细胞凋亡在正常和肿瘤组织微环境中的作用  

Roles of apoptosis in normal and tumor microenvironment

作　　者：董少婷[1] 杨红丽[1] 王爽 

机构地区：[1]南方医科大学临床医学专业,广州510515 [2]基础医学院病理学系

出　　处：《国际肿瘤学杂志》2013年第2期92-95,共4页Journal of International Oncology

基　　金：国家自然科学基金（81000953、81172242）

摘　　要：细胞凋亡是为维持机体内环境稳态而由基因控制的细胞自主性死亡，是细胞生长发育过程中的重要机制。近年来研究发现，细胞凋亡可通过直接接触或释放一系列调控因子直接或间接地影响微环境中邻近细胞的生理过程，在构建肿瘤微环境中有重要作用。了解细胞凋亡在正常和肿瘤组织微环境中的作用对深入研究肿瘤的发生机制、预防及治疗具有重要意义。Apoptosis is the autonomous death of cells, which is controlled by the genes and to maintainthe homeostasis of the body. Apoptosis is the important mechanism in the cell＇s growth and development. Recent studies have found that apoptosis can affect the neighboring cells physiological process in microenvironment through directly contact or release a series of regulatory factor, which plays an important roles in the construction of tumor microenvironment. Therefore, understanding the roles of apoptosis in the normal and tumor microenvironment has great significance for further study the pathogenesis, prevention and treatment of tumor.

关 键 词：细胞凋亡 肿瘤 巨噬细胞 肿瘤微环境 

分 类 号：R730.2[医药卫生—肿瘤]