机构地区:[1]中南大学湘雅二医院医学心理研究所,长沙410011
出 处:《中华行为医学与脑科学杂志》2012年第8期680-683,共4页Chinese Journal of Behavioral Medicine and Brain Science
基 金:国家科技支撑计划课题(2009BA177B02)
摘 要:目的 探讨男性青少年的儿童期虐待与外化性行为的关系以及单胺氧化酶A (MAOA)基因启动子区域可变重复序列(VNTR)多态性对其关系的调节作用.方法 采用随机整群抽样法抽取长沙352名汉族男性中学生,用Achenbach儿童行为量表-青少年自我报告表(CBCL-YSR)和儿童期虐待问卷(CTQ-SF)对其进行测评,并鉴定其MAOA基因型.运用分层回归分析检验调节效应.结果 (1)MAOA 基因高活性与低活性两型被试在年龄[ (15.82±1.52)岁,(15.94±1.62)岁]、外化性行为[(15.13±10.14)分,(14.33±9.70)分]、虐待总分[(52.59±10.46)分,(51.39 ±7.56)分]、情感虐待[(7.63±3.31)分,(7.11±2.68)分]、躯体虐待[(6.40±2.82)分,(6.12±2.05)分]、性虐待[(6.42±3.24)分,(5.94±1.72)分]、情感忽视[(13.44±5.12)分,(13.16 ±4.83)分]及躯体忽视得分[(10.27±2.64)分,(10.44±2.53)分]上差异均无统计学意义(t=-1.789~0.678,P>0.05).(2)除情感忽视及躯体忽视外,情感虐待、躯体虐待、性虐待对外化性行为均有显著预测作用(Sβ=0.141 ~0.347,P<0.01).(3)MAOA基因不能直接影响外化性行为(Sβ=-0.023,P>0.05);MAOA基因与情感虐待交互作用有统计学意义(Sβ=-0.148,P<0.01),与躯体虐待、性虐待交互作用无统计学意义(Sβ=- 0.067,-0.005,P >0.05).结论 MAOA基因多态性在男性青少年儿童期情感虐待与外化性行为的关系间起调节作用.Objective To explore the relationship between male adolescents' childhood abuse and externalizing behaviors,and the moderating effect of monoamine oxidase A (MAOA) gene promoter region variable number tandem repeat (VNTR) polymorphism.Methods Through random cluster sampling,352 Han male middle school students from Changsha were tested by Achenbach child behavior checklist-youth self reports (CBCL-YSR)and childhood trauma questionnaire-28 item short form (CTQ-SF),their MAOA genotypes were also identified.A hierarchical multiple regression analysis was used to test the moderating effect.Results ( 1 ) Compared participates with high activity MAOA gene and that with low activity MAOA gene,there were no significant differences on age ( ( 15.82 ± 1.52) vs ( 15.94 ± 1.62 ) ),externalizing behaviors ( ( 15.13 ± 10.14 ) vs ( 14.33 ± 9.70 ) ),total abuse ( (52.59 ± 10.46) vs (51.39 ± 7.56 ) ),emotional abuse( ( 7.63 ± 3.31 ) vs ( 7.11 ± 2.68 ) ),physical abuse ( ( 6.40 ± 2.82) vs (6.12 ± 2.05 ) ),sexual abuse ( ( 6.42 ± 3.24 ) vs ( 5.94 ± 1.72 ) ),emotional neglect ((13.44±5.12) vs (13.16 ±4.83) ),physical neglect( (10.27 ±2.64) vs (10.44±2.53))(t=-1.789~0.678,P 〉 0.05 ).(2)Except emotional neglect and physical neglect,emotional abuse,physical abuse and sexual abuse could predict externalizing behaviors( Sβ =0.141 ~0.347,P 〈 0.01 ).(3) MAOA gene was not directly related to externalizing behaviors( Sβ =- 0.023,P 〉 0.05 ).There was a significant interaction between MAOA gene and emotional abuse( Sβ =-0.148,P 〈 0.01 ).The interaction between MAOA gene and physical abuse or sexual abuse showed no statistical significance( Sβ =- 0.067,- 0.005,P 〉 0.05 ).Conclusion MAOA gene polymorphism can moderate the relationship between male adolescents'childhood emotional abuse and externalizing behaviors.
关 键 词:外化性行为 单胺氧化酶A基因 儿童期虐待 调节效应
分 类 号:R749.99[医药卫生—神经病学与精神病学]
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