急性缺血性脑血管病患者脑动脉粥样硬化性狭窄的分布及相关因素分析  

Analysis of distribution and related factors of cerebral artery stenosis in the patients suffered from acute ischemic cerebrovascular disease

作　　者：陈岚[1] 瞿浩[1] 李玫[1] 

机构地区：[1]贵州省人民医院,贵阳550002

出　　处：《贵州医药》2012年第7期602-605,共4页Guizhou Medical Journal

摘　　要：目的探讨急性缺血性脑血管病患者脑动脉粥样硬化性狭窄的分布及其相关危险因素。方法选取150例2005年1月至2009年1月期间于我院住院就诊的急性缺血性脑血管病患者为研究对象。所有患者行MRI和MRA检测、及血液生化指标检测,并通过问卷形式了解高血压病史、糖尿病史等因素。采用Logistic回归分析脑动脉狭窄的危险因素。结果 (1)动脉狭窄检出率为74.00%。其中,单纯颅内动脉狭窄41.44%,单纯颅外动脉狭窄11.71%,颅外合并颅内动脉狭窄46.85%。轻度狭窄占26.13%,中度狭窄43.24%,重度狭窄30.63%。(2)高血压、糖尿病、冠心病、吸烟、LDL2C等为脑动脉狭窄的危险因素,HDL2C为保护因子。(3)根据MRI和MRA检查结果,将患者分为中度狭窄组、中度狭窄组和轻度狭窄组,随着狭窄程度逐渐变严重,CRP及IL-6有逐渐增加的趋势。结论急性脑血管病患者中的动脉粥样硬化性狭窄发生率较高,可通过控制高血压、糖尿病、冠心病、吸烟等预防急性脑血管病。Objective To know the distribution and related factors of cerebral artery stenosis in the patients suffered from acute ischemic cerebrovascular disease.Methods 150 patients who suffered from acute ischemic cerebrovascular disease and were treated in our hospital during January 2004 to January 2009 were selected as the study objects.All patients were examined with MRI and MRA.Everyone was tested blood biochemical indices.Hypertension history and diabetes history was investigated through questionnaires.Risk factors of cerebral artery stenosis were analyzed by Logistic regression.Results Incidence of cerebral artery stenosis was 74%.Constituent ratio of intracranial arterial stenosis,extracranial artery stenosis,and intracranial arterial complicated extracranial artery stenosis were 41.44%,11.71%,46.85% respectively.Constituent ratios of slight stenosis,moderate stenosis,and severe stenosis were 26.13%,43.24%,30.63% respectively.Hypertension,diabetes,coronary heart disease,smoking,LDL2C were the risk factors of cerebral artery stenosis,while HDL2C was the protective factor.The patients were divided into slight stenosis group,moderate stenosis group,and severe stenosis group according to the MRI and MRA examination.The results showed that with the stenosis level became more serious,level of CRP and IL-6 increased.Conclusion In patients suffered from acute ischemic cerebrovascular disease,incidence of cerebral artery stenosis is high.Control hypertension,diabetes,coronary heart disease,smoking may be the effective way for prevention acute ischemic cerebrovascular disease.

关 键 词：急性缺血性脑血管病 动脉粥样硬化 动脉狭窄 

分 类 号：R743[医药卫生—神经病学与精神病学]