黄精联合氟西汀治疗抑郁症的临床疗效观察  

A clinical study of combined Rhizoma Polygonati and fluoxetine in the treatment of depression

作　　者：胡婷婷[1] 徐维平[1,2] 黄莺[2] 徐婷娟[2] 魏伟[1] 胡世莲[2] 严光[2] 

机构地区：[1]安徽医科大学临床药理研究所,安徽合肥230032 [2]安徽医科大学附属省立医院,安徽合肥230001

出　　处：《安徽医药》2012年第10期1494-1496,共3页Anhui Medical and Pharmaceutical Journal

基　　金：安徽省2008年人才开发专项基金(No 2008Z049);安徽省2011年科技厅年度重点课题(No 11070403034)

摘　　要：目的观察黄精联合氟西汀治疗抑郁症的疗效。方法将60例患者随机分为两组,试验组(黄精颗粒联合氟西汀组)30例,对照组(氟西汀组)30例。疗程6周,于治疗前及治疗第2、4、6周末分别用汉密尔顿抑郁量表(HAMD)评定疗效,并记录不良反应。结果 (1)治疗结束后,两组HAMD评分较治疗前均有明显下降(P<0.01);(2)在治疗第2周和第4周后,试验组的HAMD评分较对照组显著改善,差异有统计学意义(P<0.05),试验组的有效性略高于氟西汀组,且起效较快;(3)治疗6周后,两组组间HAMD评分比较,差异无统计学意义(P>0.05),两组长期治疗效果相当;(4)试验组比对照组的不良反应较少。结论黄精颗粒联合氟西治疗抑郁症,不但可以增强后者的抗抑郁疗效,还可以减轻不良反应,疗效肯定,安全有效。Objective To explore the clinical efficacy and adverse reaction of combined rhizoma polygonati and fluoxetine in the treatment of depression.Methods Sixty depressed patients involved in this study were randomized into combined rhizoma polygonati and fluoxetine group（n=30）and fluoxetine group（n=30）,studied for 6 weeks.Clinical efficacy and adverse reactions were assessed with Hamilton depression rating scale（HAMD）before and 2nd week,4th week and 6th week after the treatment.Results（1）After the 6-week treatment,HAMD scores of each group decreased dramatically as compared to pretreatment（P0.01）;（2）After 2nd week and 4th week treatment,the total HAMD-24 score decreased significantly more in combined group than in the fluoxetine group（P0.05）;（3）After the 6-week treatment,there was no significant difference in the efficacy between the combined group and fluoxetine group（P0.05）;（4）the severity of adverse reactions in combined group was lighter than that in fluoxetine group,which had significant difference.Conclusion Combined rhizoma polygonati is a highly effective and safe treatment for depression.Combined group was significantly more effective than fluoxetine group in improving depression and has few adverse reaction.

关 键 词：抑郁症 黄精 氟西汀 

分 类 号：R749.4[医药卫生—神经病学与精神病学]