甲磺酸双氢麦角碱治疗利培酮所致高泌乳素血症及对P300的影响  

A Clinical Study on the Effect of Dihydroerergotoxine Methanesulfonate in the Treatment of Hyperprolactinemia Caused by Risperidone and P300

作　　者：邹凯[1] 刘晓伟[1] 袁菁[1] 刘亮[1] 范洁[1] 奚娟[1] 方馨怡 

机构地区：[1]中国.江苏省无锡市精神卫生中心,214151

出　　处：《中国健康心理学杂志》2013年第1期3-4,共2页China Journal of Health Psychology

摘　　要：目的探讨甲磺酸双氢麦角碱治疗利培酮所致男性高泌乳素血症的疗效以及对认知功能的影响。方法将60例利培酮所致高泌乳素血症的男性精神分裂症患者随机分为治疗组(30例)和对照组(30例),疗程8周。分别于治疗前、治疗8周末检测血清泌乳素(PRL)水平、采用副反应量表(TESS)评定副反应。对治疗组在治疗前记录P300,在治疗8周后进行P300随访。结果治疗8周末,治疗组PRL较治疗前显著下降(t=2.41,P<0.05),对照组治疗前后差异无显著性(t=0.11,P>0.05)。治疗组P300在Cz点波幅较治疗前有升高,差异有显著性(t=2.00,P<0.05)。结论甲磺酸双氢麦角碱可降低利培酮所致男性高泌乳素并能改善认知功能。Objective To explore the efficacy of dihydroerergotoxine methanesulfonate in the treatment of hyperprolactinemia caused by risperidone and the consequence of dihydroerergotoxine methanesulfonate for cognitive function.Methods A total of 60 schizophrenic patients with hyperprolactinemia associated with risperidone were randomly divided into treatment group（n=30）and control group（n=30）for 8 weeks.The prelactin（PRL）was measured at the baseline and the end of study.The efficacy and side effects were assessed with the Treatment Emergent Symptom Scale（TESS）before and after the study.Cognitive potentials（P300）were recorded for the treatment group and followed up by 8 weeks with same markers.Results The concentration of PRL was decreased significantly in treatment group after treatment（t=2.41,P0.05）.There were no significant differences before and after treatment in placebo group（t=0.11,P0.05）.The amplitude of P300 at Cz was enhanced significantly in treatment group after the study（t=2.00,P0.05）.Conclusion Dihydroerergotoxine methanesulfonate is effective in the treatment of hyperprolactinemia caused by risperidone and can improve cognitive function.

关 键 词：精神分裂症 高泌乳素血症 甲磺酸双氢麦角碱 

分 类 号：R743.33[医药卫生—神经病学与精神病学]