奥氮平与氟哌啶醇治疗难治性精神分裂症的对照研究  

A Comparison Study on Olanzapine and Haloperidal in the Treatment of Treatment-tesistant Schizophrenia

作　　者：丁婷[1] 刘玉兰[1] 

机构地区：[1]中国.山东省青岛市精神卫生中心,266034

出　　处：《中国健康心理学杂志》2013年第1期23-24,共2页China Journal of Health Psychology

摘　　要：目的比较奥氮平与氟哌啶醇治疗难治性精神分裂症的临床疗效和不良反应。方法 76例符合入组条件的难治性精神分裂症患者,随机分为两组,分别应用奥氮平和氟哌啶醇治疗12周,应用阳性和阴性症状量表(PANSS)和副反应量表(TESS)评定疗效和不良反应。结果奥氮平组有效率为65.79%,氟哌啶醇组有效率为42.11%,两组在PANSS总分、阴性症状量表分和一般病理症状量表分方面有显著性差异。结论奥氮平治疗难治性精神分裂症的疗效优于氟哌啶醇,且不良反应较少。Objective To compare the clinical efficacy and side effects of olanzapine and haloperidal in the treatment of treatment-tesistant schizophrenia.Methods A total of 76 patients with treatment-tesistant schizophrenia were randomly assigned to olanzapine and haloperidal treatment for 12 weeks.PANSS and TESS were used to assess the clinical efficacy and side effects.Results The therapeutic effect rate of olanzapine was 65.79%,and the therapeutic effect rate of haloperidal was 42.11%.There were significant differences in total score,N and G subscale score of PANSS between two groups.Conclusion Olanzapine is superior to haloperidal in the treatment-tesistant schizophrenia and less side effects.

关 键 词：奥氮平 氟哌啶醇 难治性精神分裂症 阳性和阴性症状量表 

分 类 号：R749.3[医药卫生—神经病学与精神病学]