槲皮素金属配合物的研究进展  

Progress of quercetin metal complexes

作　　者：翟广玉[1] 渠文涛[2] 马海英[1] 王俊巍[2] 颜子童[2] 

机构地区：[1]郑州大学护理学院,河南郑州450052 [2]郑州大学药学院,河南郑州450052

出　　处：《化学试剂》2013年第2期140-146,共7页Chemical Reagents

基　　金：郑州大学大学生创新创业训练计划项目(2011-cxsy165)

摘　　要：槲皮素具有广泛的生物活性和多方面的药理作用,有完整的大π键共轭体系、强配位氧原子及合适的空间构型,可与多种金属离子螯合成稳定的环状配合物。研究表明:槲皮素金属配合物具有抗癌、抗炎、抗氧化、清除自由基和降血糖等作用。槲皮素金属配合物生物活性明显高于槲皮素,药理作用显著。综述了槲皮素金属配合物的研究进展,介绍了槲皮素与主族、副族和稀土金属元素形成配合物的研究现状,为此类化合物的研究提供科学依据。Quercetin has a wide range of biological activities and pharmacological effects,a complete large π bond conjugate system,the strong coordination of oxygen atoms as well as the appropriate spatial configuration,which makes it an excellent metal ion ligand that can chelate with a variety of metal ions to form the stable ring complexes.Quercetin metal complexes have a lot of biological activities,for instance,antitumor,anti-inflammatory,anti-oxidation,scavenging free radicals and hypoglycemic.The bioactivities of quercetin metal complexes are significantly better than that of quercetin.A review is provided of the research progress on quercetin metal complexes,and introduced the complexes formed between quercetin and the metal ion of the main group,the vice-family and the rare earth elements.

关 键 词：槲皮素 金属配合物 生物活性 抗癌 进展 

分 类 号：R914.5[医药卫生—药物化学]