不同取代度磺丁基醚-β-环糊精的合成工艺研究  

Study on the Synthesis Technology of Sulfobutyl Ether β-Cyclodextrins with Different of Substitution

作　　者：杨学敏[1] 杨波[1] 廖霞俐[1] 肖丹[1] 易东[1] 秦启学[1] 

机构地区：[1]昆明理工大学生命科学与技术学院药学与制药工程技术中心,云南昆明650500

出　　处：《化学世界》2013年第2期110-113,共4页Chemical World

基　　金：国家自然科学基金(21062009)

摘　　要：研究了不同取代度磺丁基醚-β-环糊精的合成。选用1,4-磺丁基内酯为原料,以氢氧化钠水溶液为溶剂,通过正交实验考察反应时间、反应温度、β-环糊精和1,4-磺丁基内酯摩尔比、氢氧化钠的量等因素对产物平均取代度的影响。采用MS和1 H NMR对产物结构进行了表征。Sulfobutyl ether β-cyclodextrins of different degrees of substitution of were prepared, β-Cyclo- dextrin and 1, 4-sulfonylurea butyl lactone were reacted in NaOH solution. The influences of factors inclu- ding reaction time and temperature, molar ratio of β-cyclodextrin to 1, 4-sulfonylurea butyl lactone and dosage of NaOH on the average substitution degree of sulfobutyl etherβ-cyclodextrins were studied via or- thogonal experiments. Furthermore, the structures of sulfobutyl ether β-cyclodextrins were characterized by MS and ^1H NMR , respectively.

关 键 词：Β-环糊精 磺丁基醚-Β-环糊精 取代度 

分 类 号：O624[理学—有机化学]