白血病患者HBV和HCV感染率调查  

Prevalence of hepatitis B viral infection in patients with leukaemia

作　　者：孙丙虎[1] 张振华[1] 苏倩[1] 张亚飞[1] 戴钰[1] 李旭[1] 

机构地区：[1]安徽医科大学第一附属医院感染病科

出　　处：《实用肝脏病杂志》2013年第1期41-42,共2页Journal of Practical Hepatology

基　　金：国家重大基础研究计划(973)项目(2009CB526411);高等学校博士学科点专项科研基金(20093420120005)

摘　　要：目的了解白血病患者HBV和HCV感染状况。方法采用ELISA法检测256例白血病患者和377例骨折患者血清HBV标志物和抗-HCV。结果在256例白血病患者中有28例(10.9%)HBsAg阳性,显著高于骨折患者的5.6%(P<0.01);急性髓性白血病(AML)和慢性淋巴细胞性白血病(CLL)患者血清HBsAg阳性率分别为10.9%和33.3%,显著高于骨折人群(P<0.05)。结论白血病患者HBV感染率较普通住院患者高,HBV感染与白血病的发生是否具有相关性,仍需进一步大样本研究。Objective The aim of this study was to determine the carring rates of hepatitis B virus in patients with leukaemia. Methods ELISA was used for detection of HBV markers in serum in 256 patients with leukaemia and in 377 with bone fracture. Result The serum hepatitis B surface antigen （HBsAg） positivity rate was significantly higher in leukaemia group （10.9% vs 5.6%,P〈0.01） than in control group; The serum HBsAg positive rates in acute myeloid leukemia and chronic lymphocytic leukemia patients were 10.9% and 33.3%, significantly higher than that in the control group （P〈0.05）. Conclusions The prevalence of hepatitis B viral infection is higher in !eukaemia than in control group,and further study should be conducted to confirm the correlation between HBV infection and leukaemia.

关 键 词：乙型肝炎病毒表面抗原 白血病 血清 

分 类 号：R733.7[医药卫生—肿瘤]