自发性细菌性腹膜炎早期联合检测血清降钙素原及C-反应蛋白的临床意义  

Clinical significance of the combination detection of Procalcitonin and C-reactive protein in the liver cirrhosis patients complicated with spontaneous bacterial peritonitis

作　　者：赖静兰[1] 

机构地区：[1]福建省福州市传染病医院肝炎科,福州350025

出　　处：《福建医药杂志》2013年第1期65-67,共3页Fujian Medical Journal

摘　　要：目的探讨血清降钙素原(PCT)与C-反应蛋白(CRP)联合检测对自发性细菌性腹膜炎(SBP)诊断的敏感性和特异性,为临床诊断提供依据。方法用电化学发光免疫法对45例肝硬化伴SBP患者、45例肝硬化不伴SBP患者及45例普通肝炎患者测定PCT,同时用免疫荧光干式定量法检测CRP。结果与普通肝炎组比较,肝硬化伴SBP组患者血清PCT和CRP水平均明显升高(t=5.20,P<0.05;t=7.94,P<0.05);而肝硬化不伴SBP组与普通肝炎组比较,差异无统计学意义(t=1.17,P>0.05;t=1.92,P>0.05);PCT对诊断自发性腹膜炎的敏感性、特异性均高于CRP。结论血清PCT联合CRP检测诊断自发性腹膜炎更加准确。Objective To explore the sensitivity and specificity of combination detection of Procalcitonin （PCT） and C- reactive protein （CRP） in the liver cirrhosis patients complicated with spontaneous bacterial peritonitis （SBP）, and provide the evidence for clinical diagnosis. Methods The levels of PCT and CRP were detected in 45 liver cirrhosis patients complicated with SBP, 45 liver cirrhosis patients without SBP and 45 general hepititis patients. Results Compared with general hepatitis patients, the levels of PCT and CRP in liver cirrhosis patients complicated with SBP were markedly higher （t= 5.20, P〈0.05 t= 7.94, P〈0.05） ; while, there were no significantly differences between liver cirrhosis group without SBP and general hepa- titis group （t=1. 17, P〉0.05; t=1. 92, P〉0.05）. The sensitivity and specificity of PCT were better than CRP. Conclusion It is more accurate to detect PCT and CRP together in early diagnosis of liver cirrhosis complicated with SBP.

关 键 词：自发性腹膜炎 降钙素原 C-反应蛋白 

分 类 号：R572.2[医药卫生—消化系统]