外源性PS应用对早产儿SP-A、SP-D的影响  

Effect of Exogenous Surfactant Therapy on Levels of Pulmonary Surfactant Proteins A and D and the Innate Host Defense Systems

作　　者：王成祥[1] 常绍鸿[1] 

机构地区：[1]新乡市中心医院儿科,河南新乡453000

出　　处：《医学信息》2013年第3期170-171,共2页Journal of Medical Information

摘　　要：目的研究外源性Ps的应用对早产儿SP-A、SP-D的影响。方法自2011年6月～2012年1月于本院住院应用肺表面活性物质（pulmonarysuffactant，PS）治疗的早产儿共15例，测定其应用PS前、应用后3d血清内SP-A、SP-D的活性，并以健康足月儿6名为对照组。结果①早产儿应用PS前，血清SP-A、SP-D均低于对照组，差异有统计学意义；②早产儿应用PS后3dSP-A、SP-D均有明显升高，差异有统计学意义；结论应用外源性PS治疗，促进患儿SP-A和SP-D产生，有效提高早产儿先天免疫系统的功能。Objective To investigate the levels of SP-A, SP-D in peripheral blood of preterm infants who were treated with exogenous pulmonary surfactants （exPS）. Methods From Jun. 2011 to Jan. 2012, 15 cases of preterm infants who were treated with exPS, selected over the same period 6 cases of full-term healthy infants, SP-A and SP-D were detected and compared in peripheral blood. Results The results showed that SP-A and SP- D in preterm infants than that in the control group. All of that in post-surfactant were significantly higher than that in pre-surfactant. Conclusion In preterm infants, Treatment with exPS apparently stimulated the innate host defense systems.

关 键 词：肺表面活性物质 先天免疫系统 SP-A SP-D 

分 类 号：R734.2[医药卫生—肿瘤]