Ras-MAPK通路在食管癌中的研究进展  

Roles of Ras-MAPK signaling pathways in esophageal carcinoma

作　　者：昌毓穗[1] 刘季春[1] 傅华群[2] 喻本桐[1] 徐建军[3] 王一明[3] 魏益平[3] 邹书兵[2] 

机构地区：[1]南昌大学第一附属医院胸心血管外科,江西南昌330006 [2]南昌大学第二附属医院普外科,江西南昌330006 [3]南昌大学第二附属医院胸心血管外科,江西南昌330006

出　　处：《中国病理生理杂志》2013年第2期376-380,共5页Chinese Journal of Pathophysiology

基　　金：江西省卫生厅科技计划基金资助项目(No.20113055)

摘　　要：Ras蛋白是调节细胞生长和增殖信号通路的重要元件。当Ras变异时，将信号转导到下游信号元件可能引起细胞的异常增殖，导致肿瘤发生。抑制Ras及其下游信号可抑制细胞增殖和促进肿瘤细胞凋亡，研究表明Ras信号通路在食管肿瘤的发病过程中起着重要作用。Ras is best known for the ability of regulating cell growth, proliferation and differentiation. Muta- tions in Ras are associated with abnormal cell proliferation, resulting in the incidence of all human cancers. Mitogen-activa- ted protein kinase （MAPK） signaling pathways are the most well described pathways in carcinogenesis, which has been i- dentified as a key downstream effector in Ras signaling as well as playing important roles in prognosis of tumors. Recently, evidence has gradually accumulated to demonstrate that mutation in Ras or aberrant expression of MAPK has profound effects on the incidence of esophageal carcinoma, and applications of some chemotherapeutic drugs can not lead to the ex- pectant function. Further understanding of the relevant molecular mechanisms of Ras-MAPK signaling pathways will be helpful for development of efficient targeting therapeutic approaches to the treatment of esophageal cancer. In this article, the advances of Ras-MAPK signaling pathways in esophageal carcinoma are reviewed.

关 键 词：食管肿瘤 RAS蛋白 有丝分裂原活化蛋白激酶类 信号通路 

分 类 号：R363[医药卫生—病理学]