超声引导下Cool-tip冷循环射频消融系统治疗大肠癌肝转移的预后因素分析  

Prognostic Factors on Outcome of Cool-tip Radiofrequency Ablation in Liver Metastasis of Colorectal Cancer Guided by Ultrasound

作　　者：孙一欣[1] 程文[1] 王秋程[1] 杨洪艳[1] 张丹丹[1] 郭丹阳[1] 

机构地区：[1]哈尔滨医科大学附属第三医院超声科,哈尔滨市150081

出　　处：《中国超声医学杂志》2013年第2期130-133,共4页Chinese Journal of Ultrasound in Medicine

基　　金：黑龙江省自然科学基金(No.D201170)

摘　　要：目的探讨Cool-tip冷循环射频消融系统治疗大肠癌肝转移,用统计学方法分析影响其生存期的预后因素。方法对46例(共125个肝内转移灶)大肠癌患者进行射频消融治疗,观察治疗后患者的复发和生存情况。采用Kaplan-Meier模型和Log-rank检验进行单因素分析,采用COX比例风险模型进行多因素分析,分析患者可能的预后影响因素。结果分析可能影响生存期的21项单因素中,3项有统计学意义,分别为:肝功能Child-Pugh分级、初次RFA前癌胚抗原(CEA)值、治疗目的方案。与生存期相关的多因素有2项,分别为:肝功能Child-Pugh分级、治疗目的方案。结论超声引导下RFA治疗肝转移癌,影响治疗预后的因素为:肝功能Child-Pugh分级、初次RFA前癌胚抗原(CEA)值、治疗目的方案。此结果有助于指导RFA治疗。Objective To investigate the prognostic factors affecting outcome in Radiofrequency ablation（RFA） of colorectal liver metastases（CRLM） by statistics analyses. Methods We retrospectively reviewed 46 colorectal liver metastases patients with 125 lesions underwent RFA. We recorded and analyzed potential prognostic factors. KaplanMeier model and log-rank test were used in univariate analyses and COX regression model was used in multivariate analyses. Results On the univariate analysis, overall survival were significantly improved in 3 factors： carcinoembryonic antigen （CEA）〈100 ng/ml, Child-Pugh grade, treatment purpose and method. On the multivariate analysis, signifi cant survival factors were Child-Pugh grade, treatment purpose and method. Conclusions RFA for colorectal liver metastases is an effective treatment option in patients with Chil＆Pugh grade A, and in patients with CEA〈100 ng/ ml, while treatment purpose and method also had significant action on survival.

关 键 词：超声 射频消融 大肠癌肝转移 疗效 预后因素 

分 类 号：R735.34[医药卫生—肿瘤] R445.1[医药卫生—临床医学]