人肝细胞肝癌中STAT3的表达及其临床意义  

Significance of STAT3 expressions in human hepatocellular carcinoma

作　　者：司望利[1,2] 宋瑛[2] 胡雅楠[1] 任牡丹[1] 张雅欣[3] 和水祥[1] 

机构地区：[1]西安交通大学医学院第一附属医院消化内科,陕西西安710061 [2]西安市中心医院消化内科,陕西西安710003 [3]新疆克拉玛依市中心医院,新疆克拉玛依834000

出　　处：《西安交通大学学报（医学版）》2013年第2期205-209,共5页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金面上项目(No.30771895)~~

摘　　要：目的探讨人肝细胞肝癌组织(hepatocellular carcinoma,HCC)中激活转录因子3(signal transducer and activa-tor of transcription 3,STAT3)的表达及其在肝癌发病中的作用。方法利用免疫组织化学方法检测76例HCC组织中STAT3的表达情况,29例肝血管瘤患者手术切除标本中的正常肝组织作为正常对照。同时,检测环氧合酶-2(cyclooxygenase-2,COX-2)的表达情况。结果在HCC组织中STAT3表达较高,阳性表达率为68.4%(P<0.05),并与COX-2的表达呈正相关(r=0.683,P<0.05)。HCC组织中STAT3的表达与饮酒史、肿瘤直径<5cm、静脉侵犯、TNM分期Ⅰ、Ⅱ期显著相关(P<0.05)。结论在HCC发生的早期阶段STAT3与COX-2均呈高表达,STAT3/COX-2信号转导通路可能在肝癌发生早期阶段起一定的作用。Objective To investigate the expression of signal transducer and activator of transcription 3 （STAT3） in human hepatocellular carcinoma （HCC） and its significance in liver cancer. Methods Immunohistochemistry method of SP was employed to detect the expression of STAT3 in 76 HCC tissue specimens; 29 normal hepatic tissue specimens served as controls. The expression of cyclooxygenase-2 （COX-2） was detected at the same time for comparison. Results The positive expression rate of STAT3 in HCC was 68.4% （P〈0.05）, which was significantly related to the history of alcohol use, tumor diameter, vein invasion and TNM stages （ I and Ⅱ ） （P〈0.05）. The expression of STAT3 in HCC had a positive correlation with COX-2 protein level （r=0. 683, P 〈0. 05 ）. Conclusion STAT3 and COX-2 are overexpressed in HCC and may be involved in early hepatocarcinogenesis. STAT3/COX-2 related signal pathway may play an important role at the early stage of HCC.

关 键 词：环氧合酶2 信号传导与激活因子3 肝细胞肝癌 临床病理指标 

分 类 号：R735.7[医药卫生—肿瘤]