流化床侧喷技术制备淀粉颗粒的工艺研究  

Preparation of Starch Granules in Fluidized Bed by Tangential Spray

作　　者：龙园园[1] 景秋芳[1] 陈爱玲[1] 任福正[1] 

机构地区：[1]华东理工大学药学院上海市新药设计重点实验室,上海200237

出　　处：《华东理工大学学报（自然科学版）》2013年第1期47-50,共4页Journal of East China University of Science and Technology

基　　金：国家重大新药创制科技重大专项(2011ZX09102-005-02);上海市科委项目(11DZ2260600)

摘　　要：采用流化床侧喷技术制备淀粉丸芯,主要以颗粒粒径分布、流动性及表面形态为评价指标,考察了黏合剂及工艺参数对制粒效果的影响。结果表明,选择流化床进风温度70℃,进风风量60～70m3/h,雾化压力0.15MPa,在17.5g/min速度下喷入黏合剂(HPMC K100的质量分数为3%),当黏合剂的用量为起始物料质量数的3.0%时,在65～100目的颗粒收率较高,且具有良好的流动性和较规整的表面形态。The starch granules were prepared in fluid bed by tangential spray. The particle size distribution and flowability were selected to evaluate the effects of the formulation factors and process parameters on the granulation. The results show that the flowability and the yield of granule （65-100 mesh）are excellent when the inlet temperature is 70 ℃ ,blowing rate is 60--70 m3/h, atomization pressure is 0.15 MPa, spray speed is 17. 5 g/min, w=3% HPMC K100 as the adhesion agent（mass ratio of adhesion agent to starting materials is 3.0 %）.

关 键 词：流化床 侧喷技术 淀粉颗粒 

分 类 号：TQ460.5[化学工程—制药化工]