乳果糖联合双歧杆菌对慢性重型肝炎并发自发性细菌性腹膜炎患者血清内毒素及炎性因子的影响  

Effects of lactulase and bifidobacterium on patients with chronic severe hepatitis complicated with spontaneous bacterial peritonitis

作　　者：张蒙[1] 付贤云[1] 王丽娜[1] 安勇[1] 

机构地区：[1]济南市传染病医院一科,济南市250021

出　　处：《中华实验和临床感染病杂志（电子版）》2012年第6期78-80,共3页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

摘　　要：目的观察乳果糖联合双歧杆菌对慢性重型肝炎合并自发性细菌性腹膜炎患者血清内毒素(LPS)、肿瘤坏死因子(TNF-α)及白细胞介素-6(IL-6)水平的影响。方法将60例慢性重型肝炎合并自发性细菌性腹膜炎的患者随机分为两组,即对照组,行常规治疗;观察组,常规治疗基础上加用乳果糖和双歧杆菌。第0天和第7天分别检测两组患者血清中LPS、TNF-α和IL-6的含量。结果慢性重型肝炎合并自发性细菌性腹膜炎患者应用乳果糖联合双歧杆菌治疗后血清LPS、TNF-α和IL-6水平显著低于对照组(P<0.05)。结论慢性重型肝炎合并自发性细菌性腹膜炎患者血清中LPS、TNF-α和IL-6水平升高,乳果糖联合双歧杆菌治疗能有效降低血清中LPS、TNF-α和IL-6的含量。乳果糖联合双歧杆菌对慢性重型肝炎合并自发性细菌性腹膜炎患者的治疗具有积极作用。Objective To investigate the effects of lactulase and bifidobacterium on the levels of serum iipopolysaccharide （LPS）, tumor necrosis factor （TNF-α） and interleukin （IL-6） in patients with chronic severe hepatitis complicated with spontaneous bacterial peritonitis （SBP）. Methods Sixty patients with chronic severe hepatitis complicated with SBP were divided into two groups, randomly. The observation group were given a combination of lactulase, bifidobaeterium and standard medical therapy （SMT） （n = 30） and the control group were given only SMT （n = 30） for treatment. At 0 day and the 7th day,the levels of LPS, TNF-α and IL-6 in serum of the two groups were detected, respectively. Results The levels of serum LPS, TNF-α and IL-6 in patients with chronic severe hepatitis complicated with SBP were significantly increased. Compared with the control group, the levels of serum LPS, TNF-α and IL-6 were significantly decreased in the observation group（P 〈 0.05）. Conclusions Lactulase and bifidobacterium are beneficial in patients with chronic severe hepatitis complicated with SBP.

关 键 词：乳果糖 双歧杆菌 肝炎 重型 腹膜炎 内毒素 

分 类 号：R575.1[医药卫生—消化系统]