结构生物学现状及跨世纪发展趋势  

Structural Biology: Current State and Perspectives in the Coming Century

作　　者：王大成[1] 

机构地区：[1]中国科学院生物物理研究所

出　　处：《中国基础科学》2000年第6期4-9,共6页China Basic Science

摘　　要：近年来,结构生物学的发展呈现出快速增长的新态势。精确测定的生物大分子结构数目以指数曲线增加,总数已超过10 000,最高分辨率优于0.83,最大分子量10~7u,最快时间分辨率已接近10^(-9)s。同时,以精确结构知识为基础,揭示生命活动的规律已达到前所未有的深度和广度。在21世纪后基因组时代的生物学中,结构生物学具有战略性关键地位,将进入可以自由研究复杂体系和动态过程的新时期,并与基因组学“联姻”产生新的重大科学领域(结构基因组学),同时将成为揭示一系列疑难病症(如“构象病”)分子机理以及创新药物设计和开发的重要途径。107 u. Meanwhile the structural analyses combined with the functional implication have gained insight into mechanisms of many biological processes. In the coming century, the structural biology will stand at the frontier of the post-genome era and play a crucial strategic role in developing new biological sciences. The structural biology will be married with the genomics to create a new big science, structural genomics. In this novel era the complex system and the dynamic process in organisms may be investigated freely. Integrating structures with functions will be a tidal current which will reveal mechanisms of many difficult diseases like AIDS and neurodegenerative diseases and also provide rational approach to discovery of novel drugs for the medical usage. Recent years the structural biology has been developing very fast and growing into a new phase. The total number of determined bio-macromolecular structures is more than 10 thousand now and still going up exponentially. The resolution and the time-resolved scale of the structure determination have reached 0.83 A and nanosecond respectively. The mass of the determined structure comes up to

关 键 词：结构生物学 生物大分子结构 发展趋势 药物设计 

分 类 号：Q501[生物学—生物化学]