肝心同治法治疗功能性消化不良伴焦虑抑郁状态30例  

Clinical Effect of Therapy Aiming at Liver and Heart in Treatment of Functional Dyspepsia with Anxiety and Depression: A Report of 30 Cases

作　　者：谭文婧[1] 陶智会[1] 王鑫[1] 李勇[1] 李毅平[1] 汤键[1] 王健[1] 虞胜[1] 

机构地区：[1]上海中医药大学附属上海市中医医院消化科,上海200071

出　　处：《安徽中医学院学报》2013年第1期23-27,共5页Journal of Anhui Traditional Chinese Medical College

基　　金：上海市卫生局中医药科研项目(2010L038A);上海市卫生局医疗机构特色中药创新规范研究(2011ZJ006)

摘　　要：目的观察疏肝健脾合养心安神方治疗功能性消化不良(functional dyspepsia,FD)伴有焦虑抑郁状态的疗效。方法将90例FD伴焦虑抑郁状态的患者随机分为疏肝组、疏肝养心组和疏肝黛力新组,分别治以中药疏肝健脾方、中药疏肝健脾方+养心安神方,及中药疏肝健脾方+黛力新,治疗前后观察3组患者脾胃症状评分,采用36条目生活质量简表(36-item short form health survey questionnaire,SF-36)评价患者治疗前后的生活质量,采用汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)、汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评价患者治疗前后的焦虑抑郁水平。结果疏肝养心组、疏肝黛力新组在改善FD患者脾胃症状,降低HAMA、HAMD评分,改善SF-36各维度评分方面显著优于疏肝组(P<0.05,或P<0.01);疏肝养心组与疏肝黛力新组疗效比较,差异无统计学意义(P>0.05)。结论疏肝健脾方合养心安神方可明显改善FD伴焦虑抑郁状态患者的脾胃症状,并可改善焦虑抑郁症状,提高生活质量。Objective To observe the therapeutic efficacy of the prescription for dispersing stagnated liver qi and strengthening the spleen combined with the prescription for nourishing the heart and tranquillization in the treatment of functional dyspepsia （FD） with anxiety and depression. Methods Ninety FD patients with anxiety and depression were randomly divided into group A treated with the prescription for dispersing stagna- ted liver qi and strengthening the spleen, group B treated with the prescription for dispersing stagnated liver qi and strengthening the spleen combined with the prescription for nourishing the heart and tranquillization, and group C treated with the prescription for dispersing stagnated liver qi and strengthening the spleen as well as deanxit. The therapeutic effects of the therapy regimens were assessed based on spleen and stomach symptom scores, 36-item short form health survey questionnaire （SF-36） scores, Hamilton anxiety scale （HAMA） scores, and Hamilton depression scale （HAMD） scores. Results Groups A and B showed significantly better im- provement in spleen and stomach symptoms, HAMA and HAMD scores, and SF-36 scores than group A （P^0.05 or P^0.01）. There was no significant difference in therapeutic efficacy between group B and group C. Conclusion The prescription for dispersing stagnated liver qi and strengthening the spleen com- bined with the prescription for nourishing the heart and tranquillization can significantly relieve spleen and stomach symptoms as well as anxiety and depression and improve the quality of life in FD patients with anxiety and depression.

关 键 词：功能性消化不良 焦虑抑郁状态 汉密尔顿焦虑量表 汉密尔顿抑郁量表 36条目生活质量简表 疏 肝健脾 养心安神 黛力新 

分 类 号：R57[医药卫生—消化系统]