埋植式药物泵在晚期口腔癌化疗中的临床应用  

The clinical application of implantabledrug delivery system in advanced oral cancer chemotherapy

作　　者：青松[1] 杨晶[1] 刘震[1] 谭智[1] 沈锂[1] 

机构地区：[1]川北医学院附属医院口腔颌面外科,四川南充637000

出　　处：《四川医学》2013年第1期49-50,共2页Sichuan Medical Journal

摘　　要：目的研究应用埋植式药物泵化学治疗晚期口腔癌的价值。方法对32例晚期口腔癌患者根据肿瘤部位分别应用埋植式药物泵通过颞浅动脉逆行插管至舌动脉、颌内动脉、面动脉平面进行区域性动脉化疗。化疗药物采用顺铂、5-氟脲嘧啶、甲氨碟呤联合应用,每周期用药1周,间隔2周,重复2～6周期化疗。结果 32例晚期口腔癌患者经埋植式药物泵化学治疗后,有效率(RR)75%,其中完全缓解(CR)11例(34.38%)、部分缓解(PR)13例(40.63%)。结论应用埋植式药物泵化学治疗晚期口腔癌的有较好的临床应用价值。Objective To evaluate intra-arterial infusion chemotherapy for advanced oral cancer using subcutaneous im- plantable drug delivery system （IDDS）. Methods 32 patients with advanced oral cancer were implanted IDDS through tile super- ficial temporal artery according to the tumor site. The chemotherapy drugs were used through IDDS. Effect and side effect were ob- served. Results Response rate （RR） was 75%, and complete remission （CR） was 11 cases （34. 38% ）, partial remission （PR） was 13 cases （40. 63% ）. No Serious side effect were observed. Conclusion The application of intra-arterial infusion chemotherapy using 1DDS have good clinical value.

关 键 词：口腔癌 埋植式药物泵 动脉灌注化疗 

分 类 号：R739.8[医药卫生—肿瘤]