均匀设计法优选连翘超微粉碎工艺的研究  

Optimization of ultramicro comminution technology for Forsythia suspensa by uniform design

作　　者：彭艳红 李嫦玲 刘新义[2] 

机构地区：[1]益阳市第一中医医院,湖南益阳413000 [2]中南大学湘雅二医院,湖南长沙410013

出　　处：《药物评价研究》2013年第1期45-47,共3页Drug Evaluation Research

基　　金：湖南省科技厅重点项目(06FJ2005)

摘　　要：目的均匀设计法优选连翘超微粉碎工艺技术参数。方法采用单因素考察各粉碎工艺参数的范围,结合均匀设计、逐步回归法优选超微粉碎工艺条件。结果逐步回归方程为Y=41.083-1.029X2,r=0.9998;参照粉碎工艺参数范围及生产实际,选择连翘超微粉碎工艺条件为粉碎时间18min,温度?10～10℃,水分5%～9%,介质填充率60%～70%,预测粒径D50为22.56μm,验证粒径D50为22.81μm。结论超微粉碎工艺条件参数与粒径相关性良好,均匀设计法对超微粉碎工艺具有较好的指导意义。Objective To optimize the technical parameters of ultramicro comminution for Forsythia suspensa by uniform design.Methods The scope of each comminution technology parameter was studied by using single-factor test,and the condition of ultramicro comminution technology was optimized by uniform design and stepwise regression.Results The stepwise regression equation was Y = 41.083-1.029X2,r = 0.999 8;According to the scope of each comminution technology parameter and the actual production conditions,the optimized technical conditions of ultramicro powder grinding of Forsythia suspense were as follows：grinding time 18 min,grinding temperature ？10—10 ℃,water content 5%—9%,medium filling rate 60%—70%,predicted particle diameter D50 22.56 μm,validation particle diameter D50 22.81 μm,which revealed that this equation had good practical guidance.Conclusion The relationship between ultramicro comminution technical parameters and particle diameter is very good,and the uniform design could guide the ultramicro comminution technology.

关 键 词：连翘 超微粉碎 均匀设计 粒径 逐步回归 

分 类 号：R283[医药卫生—中药学]