An Overview of the Highly Pathogenic H5N1 Influenza Virus  

作　　者：Jingchuan Yin Shi Liu Ying Zhu 

机构地区：[1]The State Key laboratory of Virology and College of Life Sciences, Wuhan University

出　　处：《Virologica Sinica》2013年第1期3-15,共13页中国病毒学（英文版）

基　　金：National Natural Science Foundation of China (30979144 and 81271821)

摘　　要：Since the first human case of H5N1 avian influenza virus infection was reported in 1997, this highly pathogenic virus has infected hundreds of people around the world and resulted in many deaths. The ability of H5N1 to cross species boundaries, and the presence of polymorphisms that enhance virulence, present challenges to developing clear strategies to prevent the pandemic spread of this highly pathogenic avian influenza (HPAI) virus. This review summarizes the current understanding of, and recent research on, the avian influenza H5N1 virus, including transmission, virulence, pathogenesis, clinical characteristics, treatment and prevention.Since the first human case of H5N1 avian influenza virus infection was reported in 1997, this highly pathogenic virus has infected hundreds of people around the world and resulted in many deaths. The ability of H5N1 to cross species boundaries, and the presence ofpolymorphisms that enhance virulence, present challenges to developing clear strategies to prevent the pandemic spread of this highly pathogenic avian influenza （HPAI） virus. This review summarizes the current understanding of, and recent research on, the avian influenza H5N1 virus, including transmission, virulence, pathogenesis, clinical characteristics, treatment and prevention.

关 键 词：Avian influenza H5N1 TRANSMISSION VIRULENCE PATHOGENESIS 

分 类 号：S852.65[农业科学—基础兽医学]