食管癌根治术前后炎性及肿瘤标志物变化的研究  

Changes of inflammatory and tumor markers in patients with esophageal cancer before and after undergoing radical resection

作　　者：张靖 

机构地区：[1]重庆市黔江中心医院,重庆黔江409000

出　　处：《海南医学院学报》2013年第2期216-218,223,共4页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(112210521)~~

摘　　要：目的:探讨胸腹腔镜联合食管癌根治术患者手术前后炎性状态及肿瘤标志物变化情况。方法:选取2010年11月～2012年7月于本院进行胸腹腔镜联合食管癌根治术治疗的45例患者为观察组,同期采用开胸手术进行治疗的45例患者为对照组,后将两组患者的手术时间、出血量、VAS评分、并发症发生率及术前及术后1、3、7d的血清炎性因子和肿瘤标志物水平进行比较。结果:观察组的手术时间短于对照组,出血量小于对照组,VAS评分及并发症发生率均低于对照组,而术后1、3、7d的血清白介素-2(IL-2)及γ-干扰素(IFN-γ)均高于对照组,人可溶性白介素-2(sIL-2R)、肿瘤坏死因子-β(TNF-β)、肿瘤坏死因子-α(TNF-α)及人超敏C反应蛋白(hs-CRP)均低于对照组,差异有统计学意义(P均<0.05),而两组血清CA125、CEA、Cy211、CA199、CA724及CA50比较差异无统计学意义(P均>0.05)。结论:胸腹腔镜联合食管癌根治术可有效控制机体的炎性状态,并可达到较佳的降低血清肿瘤标志物的目标。Objective： To study the changes of inflammatory state and tumor marker in patients with esophageal cancer before and after undergoing thoracoscopic combined with laparoscopic radical resec- tion of esophageal. Methods：Forty--five patients underwent thoracoscopic combined with laparoseopic rad- ical resection of esophageal cancer in our hospital from November 2010 to July 2012 were selected as obser- vation group,and 45 patients underwent thoracotomy at the same time were selected as control group, then length of operation,blood loss volume, VAS score,incidence of complications and levels of serum inflam- matory factors and tumor markers before and 1,3 and 7 days after the operation were compared. Results： The length of operation of observation group was shorter, blood loss volume was smaller, incidence of complications was lower, VAS score was lower than that of the control group, serum IL-2 and IFN-Tafterlevels of the observation group 1,3 and 7 days after undergoing the operation were higher than that of the control group, but sIL-2R,TNF-β,TNF-α and hs-CRP levels were lower. （P all〈0.05）. No significant difference in serum CA125, CEA, Cy211, CA199, CA724 and CAS0 levels was observed between the two groups （P all〈0.05）. Conclusion. The thoracoscopic combined with laparoscopic radical resection of esoph- ageal cancer can effectively control the inflammatory state of body,and it can effectively reach the goal of decreasing the serum tumor marker levels.

关 键 词：胸腹腔镜食管癌根治术 炎性状态 肿瘤标志物 

分 类 号：R735.1[医药卫生—肿瘤]