大肠癌转移相关基因表达调控的生物信息学分析  

Bioinformatics Analysis of Gene Expression Regulation Associated with Colorectal Cancer Metastasis

作　　者：齐鲁[1] 丁彦青[1,2] 

机构地区：[1]南方医科大学基础医学院病理学系,广州510515 [2]南方医科大学南方医院病理科,广州510515

出　　处：《基因组学与应用生物学》2013年第1期83-90,共8页Genomics and Applied Biology

摘　　要：大肠癌是常见的消化道恶性肿瘤,在中国呈逐年上升的趋势。对大肠癌发生发展转移的研究能够指导临床治疗,对研发新药也有着重要意义。本文通过对表达谱数据进行分析,通过表达谱差异数据进行功能富集,研究了大肠癌转移前的早期原发肿瘤的转录调控特点以及远隔器官转移后的大肠癌的转录调控特点,筛选出了部分能够受到多重调控并在转移后肿瘤组织中高表达的关键基因,通过对这些基因相互作用关系研究,构建出转移后关键基因相互作用调控网络,为大肠癌的治疗提供更多潜在靶点。Colorectal cancer is a common gastrointestinal malignancy cancer that shows an increasing trend in China these years. Study of colorectal cancer occurrence and metastasis can guide clinical treatment, which is also of great significance in research and development of new drugs. In this article, collecting gene expression data, as well as functional enrichment of differential data of gene expression profile were analyzed to figure out the transcriptional regulation characteristics of the early primary tumors before the colorectal cancer metastasis, a part of key genes have been screened that can be multiple regulated and of high expression in the transferred tumor tissue. From researches of interactions between these genes, we can build an interactional regulation network among key genes and find more potential targets for therapy of colorectal cancer.

关 键 词：大肠癌 调控网络 MIRNA 转录因子 

分 类 号：R735.34[医药卫生—肿瘤]