中药对中晚期三阴乳腺癌的生存影响及中医治疗策略探讨  

Effect of Herbs on Progress-free Survival in Clinical Stage II ～ IV Triple Negative Breast Cancer and Strategy of Traditional Chinese Medicine

作　　者：卢雯平[1] 徐兵和[2] 姜翠红[1] 高雅静[1] 马飞[2] 车焕丽[1] 郑洪刚[1] 李道睿[1] 石闻光[1] 张培彤[1] 林洪生[1] 

机构地区：[1]中国中医科学院广安门医院肿瘤科,北京100053 [2]中国医学科学院肿瘤医院内科

出　　处：《世界中医药》2013年第1期53-55,共3页World Chinese Medicine

基　　金：中国中医科学院乳腺癌优势病种课题资助(编号:CACMSO7Y0015)

摘　　要：目的:观察辨证服用中药对三阴乳腺癌的生存影响并探讨中医治疗策略。方法:采用队列研究的方法依据治疗方法的不同将101例三阴乳腺癌分为2个队列,辨证服用中药联合西医治疗队列及单纯西医治疗队列。中药1剂/d,服药至少半年或至肿瘤进展;西医按照美国综合癌症治疗网指南给予相应的治疗。随访3年观察患者3年疾病无进展生存(PFS)及患者生存质量。结果:Kaplan–Meier生存曲线显示,中西医结合组的3年PFS较单纯西药治疗组显示一定优势,有统计学意义(P<0.05)。COX回归分析2组未见统计学意义(P>0.05)。化疗脑及肢体麻木症状在服药1个月后统计显示有明显改善(P<0.05)。结论:辨证服用中药可能对患者的生存有益,需要扩大病例数进一步研究证实。中药可改善因化疗引起的麻木及化疗脑,从而提高生活质量。Objective：We observed the effect of Chinese medicine, given as a result of syndrome differentiation, on the progress-free survival and life quality of patients with triple negative breast cancer （TNBC） as well as the strategy of traditional Chinese Medicine. Method： 101 patients at stage II/IIII/IV were divided into two cohorts, of which 65 cases were treated with combination of herbs and standard western medicine and 36 cases by the western medicine alone. Progress-free survival and symptoms like numbness and chemo- brain were evaluated. Results： During 36-month follow-up, there was a statistically significance in DFS by Kaplan-meier although no significance in DFS by COX, and there were significances in improvement of numbness and chemo-brain in combination. Conclusion： Chinese medicine treatment according to syndrome differentiation, may be beneficial to patients with TNBC, the efficacy needs to be fur- ther proved on a larger number of patients. Chinese medicine can improve quality of life by relieving the symptoms such as numbness and chemo brain caused by chemotherapy.

关 键 词：辨证中药 三阴乳腺癌 无进展生存 生存质量 

分 类 号：R737.9[医药卫生—肿瘤]