ER、PR、Cerb-B2、P53在乳腺粘液癌中的表达的研究  

Expressions of ER、PR、Cerb-B2、P53 An Mucinous Carcinoma of the Breast

作　　者：张涛[1] 

机构地区：[1]山东费县人民医院普外科,山东费县273400

出　　处：《医学信息》2013年第4期363-364,共2页Journal of Medical Information

摘　　要：目的观察ER、PR、Cerb—B2和肿瘤抑癌基因产物P53蛋白在乳腺粘液癌组织中的表达并探讨其临床意义。方法应用免疫组织化学LDP方法对42例乳腺粘液癌标本ER、PR、Cerb-B2、和P53蛋白表达进行检测，并结合临床病理资料进行统计分析。结果42例乳腺粘液癌，有淋巴结转移的10例患者中混合性粘液癌为7例，单纯性粘液癌3例，两者之间存在相关性（P=0．027，r=0．367）；ER阳性表达率80．9％，PR阳性表达率85．7％，c-erbB-2阳性表达率47．6％，p53阳性表迭率45．2％，ER表达和组织类型有关（P=0038、r=0．369），与P53的表达相关（P=0．04，r=0．319）。结论联合检测Cerb—B2受体P53蛋白在乳腺粘液癌中的表达，并分析与激素受体状况、临床病理因素之间的关系．有助于评估乳腺粘液癌的的生物学行为，对其治疗方案的制定有重要的参考价值。Objective Observe the expressions of ER,PR,Cerb-B2, tumor suppressor gene product P53 protein in breast mucinous carcinoma and its clinical significance. Methods Immunohistochemistry（LDP） method was used to detect the expressions of ER,PR,Cerb-B2,P53 in 42 cases of mucinous carcinoma of the breast ,Statistical analyses were used to study the relationship between the test results and different clinicopathological parameters. Results 42 cases of mucinous breast cancer, there are 10 cases of lymph node metastasis in patients with mixed mucinous carcinoma of 7 cases, 3 cases of pure mucinous carcinoma,The axillary＇s metastasis node numbers was related to the different histological types, p=0.027,r=0.367 ;The expressions of ER,PR,Cerb-B2,P53 in this group were 80.9%,85.7 %,47.6 %,45.2 %, respectively;the ER was distinctly related to the different histological types and the expressions of P53,（P〈O.05）; And no relationship was found between ER,PR,Cerb-B2,P53 protein in mucinous carcinoma of the breast and patient＇s age, menstrual status, axillary lymph node metastasis.Conclusion Combined detection of P53 protein in mucinous breast carcinoma and analysis of hormone receptor status and clinicopathological factors can help assess the biological behavior of the mucinous breast carcinoma and have important reference value to therapy.

关 键 词：雌激素受体 孕激素受体 Cerb—B2受体 P53蛋白乳腺粘液癌 

分 类 号：R735.34[医药卫生—肿瘤]