非小细胞肺癌患者化疗前后生活质量及焦虑情绪的影响因素分析  

Analysis of influencing factors of quality of life and anxiety of non- small cell lung cancer patients before and after chemotherapy

作　　者：胥常琴[1] 

机构地区：[1]山东省莱芜市人民医院肿瘤内科,271100

出　　处：《中国实用护理杂志》2013年第3期37-40,共4页Chinese Journal of Practical Nursing

摘　　要：目的通过分析比较非小细胞肺癌患者化疗前后的生活质量及焦虑情绪的变化，探讨化疗对于肺癌患者生活质量及焦虑情绪的影响。方法采用EORTCQLQ-C30及Zung焦虑自评量表（SAS）对64例非小细胞肺癌患者于化疗前、化疗2周期后、化疗4周期后进行临床疗效评估。结果化疗前生活质量方面疲乏、呼吸困难项目得分较高，伴焦虑情绪的患者占58％，平均SAS得分为（49．7±5．8）分；焦虑症状与失眠有相关性；化疗2周期后，患者呼吸困难得分较前下降，食欲丧失、失眠得分升高，与化疗前比较有显著差异；化疗4周期后患者角色、躯体、情绪、社会功能得分明显下降，恶心呕吐、便秘、食欲不振及经济困难条目得分明显上升，与化疗前2周期相比有显著差异；焦虑症状与疲乏、便秘及失眠相关。结论非小细胞肺癌在化疗过程中，部分患者躯体症状得到缓解，但焦虑情绪明显增加，生命质量有所下降，因此护理人员应当及时准确评价患者生活质量及情绪改变并针对性地加强护理措施，提高患者生活质量。Objective This study aims to observe the changes in quality of life as well as the anxiety among non-small cell lung cancer patients before and after chemotherapy,and to explore the effect of chemotherapy on quality of life and anxiety. Methods EORTC QLQ-C30, and SAS were used to investigate clinical treatment effect before chemotherapy, one week after two courses of chemotherapy, and one week after four courses of chemotherapy. Results Before chemotherapy, fatigue and dyspnoea scores were high, the rate of anxiety was 58%, while the SAS score was （49.7±5.8）. Anxiety was found to be positively correlated with insomnia. After two courses of chemotherapy, dyspnoea scores decreased, while insomia and appetite loss scores increased. The difference was statistically significant. After four courses of chemother- apy, the physical, role, emotional, and social function scores decreased, while the nausea and vomiting, appetite loss, constipation, and financial impact scores increased. The difference was statistically significant, anxiety was significantly positively correlated with fatigue, insomnia and constipation. Conclusions A number of patients have experienced symptom relief, but during chemotherapy, the patients had significant anxiety. Thus, quality of life decreased. The quality of life and emotions of non-small cell lung cancer patients should be evaluated, and positive psychological intervention should be given to improve quality of life.

关 键 词：非小细胞肺癌 化疗 生活质量 焦虑 

分 类 号：R734.2[医药卫生—肿瘤]