白介素-10基因819T/C多态性与克罗恩病相关性的Meta分析  

Association between interleukin-10-819 promoter polymorphism and susceptibility to Crohn’s disease:A meta-analysis

作　　者：谭诗云[1] 吴鹏波[1] 张国[2] 罗和生[1] 叶会兰[2] 

机构地区：[1]武汉大学人民医院消化内科,湖北省武汉市430060 [2]广西壮族自治区人民医院消化内科,广西壮族自治区南宁市530021

出　　处：《世界华人消化杂志》2012年第35期3603-3608,共6页World Chinese Journal of Digestology

摘　　要：目的:探讨白介素-10(interleukin-10,IL-10)基因819T/C多态性与克罗恩病(crohn's disease,CD)风险的相关性.方法:计算机检索CBM、CNKI、PubMed和EMbase数据库,收集从建库至2012-08关于IL-10基因819T/C多态性与CD风险相关性的病例对照研究.采用RevMan5.1.4软件计算合并效用量OR及其95%CI,运用Egger's回归法、Begg秩相关法检测论文发表偏倚.结果:共纳入11个研究,1670例患者和3312例对照.各遗传模型Meta分析结果显示IL-10基因819T/C多态性多态性与CD风险的相关性无统计学意义[共显性遗传模型T/TvsC/C:OR=0.90,95%CI(0.70,1.17);T/CvsC/C:OR=0.84,95%CI(0.56,1.27);显性遗传模型:OR=0.97,95%CI(0.86,1.10);隐性遗传模型:OR=0.90,95%CI(0.71,1.14)].结论:基于目前研究结果显示,IL-10基因819T/C多态性与CD风险无明显相关性.受纳入研究质量和数量限制,上述结论尚待更多高质量的前瞻性研究进一步验证.AIM：To explore the association between interleukin-10 （IL-10） 819T/C polymorphism and Crohn’s disease susceptibility. METHODS：A systematic search of electronic databases such as CBM, CNKI, PubMed, Elsevier and EMbase was performed to retrieve relevant studies. Pooled odds ratios （ORs） with 95% confidence intervals （95% CI） were calculated using the RevMan 5.1.4 software, and publication bias was tested by Egger’s regression test and Begg’s test. RESULTS：A total of 11 studies involving 1670 patients with Crohn’s disease and 3312 healthy controls were identified. The results of meta-analyses showed no significant association between IL-10 819T/C polymorphism and susceptibility to Crohn’s disease （for T/T vs C/C： OR = 0.90, 95% CI： 0.70 to 1.17; T/C vs C/C：OR = 0.84, 95% CI： 0.56 to 1.27; for dominant inheritance model： OR = 0.97, 95% CI 0.86 to 1.10; for recessive inheritance model： OR = 0.90, 95% CI： 0.71 to 1.14）. CONCLUSION：Current evidence strongly suggests that there is no significant association between IL-10 819T/C polymorphism and susceptibility to Crohn’s disease.

关 键 词：克罗恩病 白介素-10 819T C 基因多态性 META分析 

分 类 号：R574[医药卫生—消化系统]