miR-15家族在肝脏疾病中的作用  

Recent perspectives on the role of microRNAs of the miR-15 family in liver disease

作　　者：马丽霞[1] 韦新焕[1] 张晶[1] 

机构地区：[1]首都医科大学附属北京佑安医院人工肝中心,北京100069

出　　处：《临床肝胆病杂志》2013年第2期158-161,共4页Journal of Clinical Hepatology

基　　金："艾滋病和病毒性肝炎等重大传染病防治"科技重大专项基金资助项目(2012ZX10002004-006);北京市朝阳区艾滋病和病毒性肝炎等重大传染病综合防治示范区建设研究资助项目(2012ZX10004904)

摘　　要：微小RNA(miRNA)是一类最新发现的短小内源性非编码RNA,其中miR-15家族生理状态下参与细胞凋亡、分化与周期调控、应激等重要细胞功能活动的调节,而在病理状态下与多种人类疾病如肿瘤、心血管疾病、神经退行性疾病等相关,具有潜在的治疗前景。本文就miR-15家族在肝癌、急性肝衰竭、肝纤维化和慢性肝病中的重要功能及治疗应用前景作一综述。Since their recent discovery,microRNAs（miRNAs）,a class of short endogenous non-coding RNAs,have gained substantial research attention for their critical roles in a broad range of physiologic and pathogenic processes.Under normal physiological conditions,the miR-15 family members regulate several important cellular functions,including apoptosis,cell differentiation,cell cycle,and stress responses.However,under pathological conditions,the miR-15 family members contribute to carcinogenesis,cardiovascular dysfunctions,and neurodegeneration;these activities may represent potentially useful targets of molecular therapeutic strategies.In this review,we summarize and discuss the important functions and promising therapeutic applications of the miR-15 family in liver cancer,acute liver failure,liver fibrosis,and liver damage.

关 键 词：微RNAS 肝炎 慢性 肝硬化 肝功能衰竭 急性 癌 肝细胞 

分 类 号：R575[医药卫生—消化系统]