从“细胞移植”到“细胞归巢”——临床牙周组织再生的新希望?  

From “cell transplantation” to “cell homing”——New hopes for clinical periodontal tissue regeneration?

作　　者：雷鸣[1,2] 陈发明[1,2] 

机构地区：[1]第四军医大学口腔医学院转化医学中心,陕西西安710032 [2]第四军医大学口腔医学院牙周黏膜病科,陕西西安710032

出　　处：《医学争鸣》2013年第1期31-34,共4页Negative

摘　　要：干细胞移植作为牙周组织再生治疗的新方法已经取得明显进展。然而,其临床转化目前却面临着技术困难和准入制度等方面的严峻挑战。机体内已经存在很多可供组织修复再生需要的干细胞,诱导、动员这些干细胞定向迁徙、靶点募集(细胞归巢)并发挥治疗作用,有望实现牙周内源性再生,加速牙周再生治疗的临床转化进程,值得深入研究。Stem cell-based therapy has been one of the best documented strategies in periodontal regenerative medicine. However, the ex vivo manipulation of stem cells and their h7 vi^v delivery are restricted by the excessive cost of commercialization and the anticipated difficulties of regulatory approval for clinical translation. An alternative to adoptively transferred stem cells is cell populations that have already been present in a patient＇s body, which can be actively attracted to the sites of injury lbr therapeutics. This technique, known as stem cell homing, has the potential to provide new therapeutic options for h7 situ periodontal regeneration. Periodontal tissue regeneration that relies on endogenous stem/progenitor cell homing, local tissue responses, and functional stimulation thus offers new insights into h7 vivo tissue engineering and holds great promise for the future of translational medicine.

关 键 词：细胞归巢 牙周内源性再生 临床转化 

分 类 号：R783[医药卫生—口腔医学]