纤维蛋白黏合剂联合自体结膜移植治疗手术源性浅层巩膜坏死分析  

Fibrin glue with conjunctival autograft in the treatment of surgically induced necrotizing scleritis

作　　者：董诺[1] 李程[1] 叶向彧[1] 刘昭升[1] 商旭敏[1] 李学治[1] 吴护平[1] 

机构地区：[1]厦门大学附属厦门眼科中心眼表与角膜病科,厦门361001

出　　处：《中国实用眼科杂志》2013年第2期217-219,共3页Chinese Journal of Practical Ophthalmology

基　　金：国家自然基金（81000367）;福建省自然基金（2010D023）;厦门市科技计划项目（3502220094027;3502220114009.）

摘　　要：目的观察纤维蛋白黏合剂联合自体结膜移植治疗手术源性浅层巩膜坏死手术的临床效果。方法采用非随机回顾性系列病例研究。选择2007年6月至2011年6月在厦门大学附属厦门眼科中心住院的14例（14只眼）不同病因手术源性浅层巩膜坏死患者，根据病灶的大小和形状，采用纤维蛋白黏合剂辅助自体结膜移植术治疗，术后随访6－12个月，观察患者术后结膜植片、巩膜情况及并发症。结果14例患者结膜瓣均成功贴附巩膜生长良好，术后2－4周不适症状得到完全缓解。3只眼滴用糖皮质激素后曾出现眼压升高，经及时改用普拉洛芬滴眼后眼压控制正常。与术前相比，术后3眼（21．43％）最佳矫正视力提高，11只眼不变（78．57％）。随访1年，所有术眼无巩膜坏死复发。结论纤维蛋白黏合剂辅助自体结膜移植治疗手术源性浅层巩膜坏死是一种较为简便、安全、有效的手术方式。Objective To observe the clinical effect of fibrin glue （FG） with conjunctival autograft in the treatment of surgically induced necrotizing scleritis using conjunctival autograft transplantation. Methods Noncomparative interventional case series. In 14 eyes of 14 patients with surgical- ly induced necrotizing scleritis （SINS）, fibrin glue （FG） with conjuncfival autograft was performed. Postoperatively, the graft status and postoperative complications were recorded. Results After surgery, no autograft dislocation and necrotizing scleritis occurred during the follow-up period. All symptoms and signs steadily reduced, except 3 cases with elevated intraocular pressure postoperatively, 3 patients had improved best corrected visual acuity while 11 patients had the same BCVA. Conclusions Fibrin glue （FG） with conjunctival autograft surgery for SINS is feasible, technically easy, safe and effective. It can be one of the surgical treatment options for SINS.

关 键 词：纤维蛋白黏合剂 自体结膜 巩膜坏死 

分 类 号：R779.6[医药卫生—眼科]