LASIK术负压吸引高眼压对角膜表面形态影响的实验研究  

Experimental study on the effect of high intraocular pressure after LASIK negative suction on the corneal surface morphology

作　　者：刘育霞[1] 梁山[1] 王平[1] 

机构地区：[1]潍坊医学院附属医院眼科,山东省潍坊市261031

出　　处：《中国实用眼科杂志》2013年第2期239-241,共3页Chinese Journal of Practical Ophthalmology

摘　　要：目的通过模拟LASIK术负压吸引高眼压对兔眼角膜表面形态的影响，探讨LASIK术负压吸引高眼压对人眼角膜表面形态的影响，推断高眼压与角膜扩张、继发圆锥角膜的关系。方法选取新西兰大白兔24只（48只眼），按LASIK术负压吸引时间60S负压吸引，不进行角膜瓣制作，不进行激光切削，角膜地形图观察负压吸引后即刻、1h、4h、17h、24h角膜前、后表面高度及角膜前表面曲率的变化。结果24只兔48只眼负压吸引60S后即刻、1h、4h、17h角膜前、后表面高度、角膜前表面曲率与吸引前比较数值增大，差异有统计学意义，负压吸引后24h角膜前、后表面高度、角膜前表面曲率与吸引前比较逐渐恢复，差异无统计学意义。结论LASIK术负压吸引高眼压可引起角膜前、后表面高度增加、角膜前表面曲率增大、角膜前凸，但变化在负压吸引24h后恢复正常。Objective To investigate the effect of high intraocular pressure （IOP） after LASIK negative suction on human corneal surface morphology and to infer the relationship between high IOP and post-LASIK keratectasia, secondary keratoconus. Methods Twenty-four New Zealand rabbits （48 eyes） were received negative suction 60 seconds according to LASIK negative suction, there＇ s no corneal flap making and no laser cutting. The change of anterior and posterior corneal surface height and anterior corneal surface curvature were observed after negative suction immediately, 1 hour, 4 hours, 17 hours, and 24 hours on corneal topography. Results The data of 24 rabbits （48 eyes）＇s anterior and posterior corneal surface height and anterior corneal surface curvature after negative suction 60s immediately, 1 hour, 4 hours, 17 hours increased comparing with suction before, the difference being statistically different. While 24 hours＇ data gradually recovered, the difference being not statistically significant. Conclusions High IOP after LASIK negative suction can cause the height of anterior and posterior corneal surface increase, the curvature of anterior corneal surface enlarge and corneal lordosis, but changes return to normal after negative suction 24 hours.

关 键 词：LASIK 高眼压 角膜表面形态 

分 类 号：R778.11[医药卫生—眼科]