苏州地区妇科疾病患者人乳头状瘤病毒感染状况分析  

Analysis of hmnan papiUomavirus infection stains of gynecological patients in Suzhou

作　　者：陈昭华[1] 徐红星[1] 赵星[1] 朱琴芳[1] 俞钱[1] 

机构地区：[1]南京医科大学附属苏州市立医院本部检验科,215002

出　　处：《国际流行病学传染病学杂志》2013年第1期8-12,共5页International Journal of Epidemiology and Infectious Disease

摘　　要：目的了解苏州地区妇科疾病患者中人乳头状瘤病毒（HPV）感染状况和各亚型分布。方法采集2010---2011年苏州地区2183例患有不同程度宫颈疾病的妇科患者宫颈脱落细胞，应用流式荧光杂交技术检测HPV26种亚型（低危亚型7种、高危亚型19种），分析比较2010年与2011年HPV感染率、各亚型分布及不同年龄段HPV的感染情况。结果HPV总感染率为40．2％，单一亚型感染率高于多重亚型（27．9％：12．3％，X^2=166．73，P〈0．01），低危亚型感染率低于高危亚型（9．8％：23．7％，X^2=149．69，P〈0．01）。低危型均以HPV6、11亚型感染为主；高危型以HPV16、52、58亚型为主。年龄在50-59岁HPV感染率最高（51．4％），30～39岁HPV感染率最低（35．2％），各年龄段HPV感染率差别有统计学意义（X^2=19．65，P〈0．05）；各年龄段高危亚型的构成比均高于低危亚型及混合型（除大于60岁年龄段外），且随年龄增加低危亚型的感染率呈下降趋势而高危亚型的感染率则增高。结论苏州地区妇科患者中HPV感染率较高，以单一亚型感染及高危亚型感染为主，常见亚型为HPV16、11、6、52、58。不同年龄段HPV感染率及感染类型构成比均不同，50～59岁是HPV感染高发年龄段，HPV的分型检测可为其感染的防治提供科学依据。Objective To explore the prevalence rate and subtype distribution of human papillomavirus （HPV） infection in gynecological patients in Suzhou. Methods The cervical exfoliated cells from 2183 patients with cervical diseases in different degree were collected between 2010 and 2011, and 26 subtypes （including 7 low risk subtypes and 19 high risk subtypes） were detected by flow fluorescence hybridization technique. The prevalence rate and subtypes distribu- tion as well as I-IPV infection in different ages between 2010 and 2011 were analyzed. Results The overall I-IPV preva- lence rate was 40.2%. The prevalence rate of single infection was higher than that of multiple infection （27.9% ： 12.3%, X^2 = 166.73, P 〈 0.01） and prevalence rate of low-risk HPV types was lower than that of high-risk subtypes （9.8 % ： 23.7 %, X^2= 149.69, P 〈 0.01 ）. The major subtypes in low-risk HPV were HPV 6 and 11. The most common high-risk subtypes were HPV 16, 52 and 58. The highest HPV prevalence rate was found at the age of 50-59 years （51.4%） and the lowest HPV prevalence rate was found at the age of 30-39 years （35.2%）. I-IPV prevalence rate was associated with age（ X^2 = 19.65, P 〈 0.05）. The constituent ratio of high-risk subtypes at every age group （except age of 〉 60years group） was higer than low-risk and mixed subtypes. Meanwhile, the low-risk subtype infection rates decreased and the multiple subtype infection rates increased with the age increasing. Conclusions The infection rate of HPV is high in gynecological patients in Suzhou area. The common infected type is single infection and high-risk subtype. HPV16, 11, 6, 52 and 58 are the most common subtypes. Composition ratio of HPV infection rates and infection types are significantly different in the different age groups, the 50-59 years old group was snsceptibles. The subtype analysis of HPV can provide scientific evidence in HPV prevention and treatment.

关 键 词：乳头状瘤病毒感染 妇科病患者 发病率 流式荧光杂交法 

分 类 号：R737[医药卫生—肿瘤]