组织因子在结直肠癌患者及其他恶性肿瘤患者血清中的表达及其意义  

Expression and clinical significance of tissue factor in serum of patients with colorectal cancer and/or other malignant tumors

作　　者：关亚伟[1,2] 安萍[1] 蔡慧云[1] 

机构地区：[1]北京军区总医院普通外科全军普通外科中心,100700 [2]北京军区总医院泌尿外科,研究生100700

出　　处：《中华普外科手术学杂志（电子版）》2013年第1期48-50,共3页Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)

基　　金：国家自然科学基金资助项目(30772118)

摘　　要：目的研究血清组织因子(TF)在结直肠癌患者及其他恶性肿瘤患者中的表达及意义。方法应用酶联免疫方法检测406例结直肠癌患者、其他恶性肿瘤患者(胃癌89例、乳腺癌78例及甲状腺癌54例)及良性疾病患者(乳腺良性病51例、甲状腺良性病48例)血清中TF水平,205例正常人作为对照。结直肠癌患者血清同步做TF和肿瘤标志物CEA、CA242、CA199,比较其阳性率。结果结直肠癌组、胃癌组患者血清TF检出率最高,分别为:66.7%和66.2%;其次为乳腺癌组42.3%;甲状腺和乳腺良性疾病组、甲状腺癌组和正常对照组均无阳性表达。统计学分析显示:结直肠癌组、胃癌组和乳腺癌组与甲状腺和乳腺良性疾病组、甲状腺癌组和正常对照组差异有统计学意义(P<0.01)。血清TF含量比较:结直肠癌组[(1.45±1.04)U/L]明显高于正常人组[(0.17±0.15)U/L]、甲状腺癌组[(0.20±0.04)U/L]及良性病组[乳腺良性病(0.15±0.16)U/L;甲状腺良性病(0.19±0.18)U/L],(P<0.01);结直肠癌组与胃癌组[(2.05±1.34)U/L]差异无统计学意义。406例结直肠癌患者血清TF与同期血清CEA、CA242和CA199阳性率分别为66.7%、44.1%、34.5%和37.7%,TF阳性检出率明显高于CEA、CA242和CA199,差异有非常显著性统计学意义(P<0.01)。结论血清中TF的检测是一种预见性的检查,比常规血清肿瘤标志物更敏感些,有可能成为结直肠癌早期诊断及评价预后的有价值的一项指标。Objective To investigate the expression of tissue factor （ TF ） in serum of patients with coloreetal cancer and/or other malignant tumors, and to evaluate its clinical significance. Methods 406 patients with colorectal cancer, patients with other malignancies （ 89 patients with gastric cancer, 78 patients with breast cancer and 54 patients with thyroid cancer） , and 99 patients with benign diseases （51 patients with benign breast diseases and 48 patients with thyroid benign diseases ） were detected by enzyme immunuassay for serum levels of TF. 205 normal persons were served as controls. The serum of patients with eolorectal carcinoma were detected simultaneously for tumor markers such as CEA, CA242, and CA199, and the positive rate was compared with that of TF . Results In gastric cancer and colorectal cancer groups, the rate of TF expression was 66.7% and 66.2% respectively. The rate of TF expression was 42.3% in the breast cancer group, hut no expression of TF could be detected in the thyroid and breast benign diseases group, thyroid cancer group and control group. There was no significant difference between the above mentioned groups（P 〈0.01 ）. The serum TF [ （ 1.45 ± 1. 04） U/L] was higher in the colorectal cancer group than in the normal controls [ （0.17 ± 0.15 ） U/L], the thyroid cancer group [ （0.20 ± 0.04） U/L], the benign disease group [ breast benign disease（0. 15 ± 0. 16） U/L, and in the thyroid benign diseases group（0.19 ±0.18） U/L] （ P 〈0.01 ）. In the colorectal cancer group and gastric cancer group[ （ 2.05 ± 1.34） U/L] there was no statistically significant difference. Conclusion Serum TF detection is an antieipatory examination, and it is more sensitive than conventional tumor markers. It might be used as a early diagnostic and predictive prognosis factor for colorectal cancer.

关 键 词：凝血致活酶 结直肠肿瘤 肿瘤转移 

分 类 号：R735.3[医药卫生—肿瘤]