胃癌高发区人群胃粘膜病变与NPRO合成的相关研究  

THE RELATIONS BETWEEN URINARY N-NITROSOPROLINE EXCRETION AND GASTRIC MUCOSAL LESIONS IN HIGH RISK AREA OF GASTRIC CARCINOMA

作　　者：李爱玲[1] 王润田[1] 王天根[1] 雷道年[2] 徐国平[2] 宋圃菊[2] 

机构地区：[1]北京医科大学流行病学教研室 [2]北京医科大学病理学教研室

出　　处：《北京医科大学学报》1991年第3期188-191,共4页Journal of Peking University(Health Sciences)

基　　金：国家自然科学基金

摘　　要：为检验N-亚硝基化合物与胃癌及癌前病变的关系,本研究以山东牟平县高陵镇经胃镜筛检查出的胃癌及慢性胃炎患者为研究对象,对其空腹胃液PH值、亚硝酸盐浓度及24小时尿液N-亚硝基脯氨酸(NPRO)排出量进行了测定。结果显示,胃液PH值及亚硝酸盐浓度与胃粘膜病变程度呈正相关关系,而未见尿液N-亚硝基脯氨酸的排出量与胃粘膜病变有显著关联。For the purpose of finding the relationships between introgastric nitrosation and precancerouslesions and gastric cancer, 87 subjects, devided into three groups Ⅰ-Ⅲ, were selected in Gao-ling,Muping County, Shandong Province in 1988 in high risk area. pH value, nitrite concentration offasting gastric juice and urinary NPRO excretion were measured. A relationship was found betweenadvanced gastric lesions and pH value of gastric juice (r=0.32, P<0.01). Nitrite concentration alsoincreased in cases with more advanced gastric lesions (r=0.24, P<0.05). No high level of NPRO hasbeen detected in subjects with more advanced lesions.

关 键 词：胃癌 胃粘膜病变 NPRO 

分 类 号：R735.202[医药卫生—肿瘤]