苦参碱联合化疗药物对中晚期肺癌的疗效分析  

The Effects of Matrine Combined with Chemotherapy Drugs on Middle-late Lung Cancer

作　　者：孙建红 武建军[2] 连月珍 周辉[3] 

机构地区：[1]同煤集团肿瘤结核医院,山西大同037003 [2]同煤集团总医院,山西大同037003 [3]中南大学湘雅医学院附属肿瘤医院,湖南长沙410013

出　　处：《肿瘤药学》2013年第1期48-50,共3页Anti-Tumor Pharmacy

基　　金：湖南省医药卫生科研计划项目资助(B2012-098);湖南省科技厅科技计划项目资助(2012SK3249)

摘　　要：目的观察分析苦参碱联合化疗药物对肺癌的临床疗效。方法选择2010年8月～2012年7月间在我院接受治疗的中晚期肺癌患者90例,随机分成对照组和观察组,各45例,对照组患者仅给予IAP方案(异环磷酰胺、阿霉素和顺铂)化疗,观察组患者在此基础上选择苦参碱联合治疗,比较两组患者的疗效和不良反应。结果观察组的缓解率为77.78%(35/45),显著高于对照组的46.67%(21/45)(P<0.05);观察组患者不良反应的发生率为15.56%(7/45),显著低于对照组的51.11%(23/45)(P<0.05)。结论苦参碱联合化疗治疗肺癌患者的临床疗效显著、不良反应发生率低,值得在临床推广。objective To investigate and analyze the clinical effects of matrine combined with chemotherapy drugs on lung cancer patients. Methods 90 patients with middle-late lung cancer, who had received treatment in our hospital from August 2010 to July 2012, were chosen as subjects of the experiment. These patients were randomly divided into two groups：control group and observation group, 45 cases in each group. The former was only cured with chemotherapy drugs which are cyclophospha-mide, adriamycin and cisplatin, and the latter with these matrine combined with chemotherapy drugs. Finally, the curative ef-fects and adverse reactions were observed and compared between the two groups. Results The remission rate of the observation group was 77.8%（35/45）, significantly higher than that of the control group which was 46.7%（21/45） （P〈0.05）. In addition, the adverse reaction rate of observation group was 15.56%（7/45）, which was significantly lower than that of the control group of 51.11%（23/45） （P〈0.05）. Conclusion With distinct curative effect and low incidence of adverse reactions on lung cancer pa-tients, the matrine combined with chemotherapy drugs has very important clinical significance.

关 键 词：苦参碱 联合化疗 肺癌 临床疗效 

分 类 号：R734.2[医药卫生—肿瘤]