痰热清注射液防治头颈部肿瘤化疗所致口腔黏膜炎的疗效观察  

Observation on the Clinical Efficacy of TanReQing Injection in the Prevention and Treatment of Chemotherapy Induced Oral Mucositis in Head and Neck Neoplasm

作　　者：李亚军[1] 黄文碧[1] 邹彦[1] 阮培刚[1] 肖冬英[1] 王素华[1] 高晓霞[1] 

机构地区：[1]遵义医学院附属医院肿瘤医院,贵州遵义563000

出　　处：《肿瘤药学》2013年第1期56-59,共4页Anti-Tumor Pharmacy

摘　　要：目的探讨痰热清注射液预防和治疗头颈部恶性肿瘤化疗所致急性口腔黏膜炎的临床疗效。方法将2011年1月～2012年4月在我院首诊为头颈部恶性肿瘤且行化疗的患者120例随机分为3组,即对照组、治疗组和预防组,每组各40例,3组均采用5-氟尿嘧啶(5-Fu)联合顺铂(PDD)方案行诱导化疗,对照组化疗后出现口腔黏膜炎时予生理盐水联合庆大霉素、地塞米松、维生素B6配成漱口液,含漱3～5次/日,结合口溃散对症处理;治疗组于患者出现口腔黏膜炎时除给予对照组的常规治疗外,加用痰热清注射液治疗,预防组于开始化疗后同时予痰热清注射液治疗。治疗结束后比较三组口腔黏膜炎的发生率、化疗开始至发生口腔黏膜炎的时间、口腔炎平均治愈时间及不良反应的发生情况。结果对照组、治疗组和预防组口腔炎的发生率分别为87.5%、92.5%和80.0%,治疗组与对照组比较差异无统计学意义(P>0.05)。而预防组较前两组显著降低(P<0.05)。对照组、治疗组和预防组的重度口腔炎(Ⅲ～Ⅳ级)发生率分别为52.5%、57.5%和27.7%,治疗组与对照组比较差异无统计学意义(P>0.05),而预防组显著低于前两组(P<0.05)。对照组、治疗组和预防组从开始接受化疗到开始出现口腔炎的平均时间分别为7.3天、7.8天、13.3天,治疗组与对照组比较差异无统计学意义(P>0.05),而预防组与前两组相比显著延长(P<0.05)。对照组、治疗组和预防组口腔炎平均治愈时间分别为7.5天、4.6天、3.5天,治疗组的平均治愈时间明显短于对照组(P<0.05),预防组的平均治愈时间明显短于前两组(P<0.05)。结论预防使用痰热清注射液可对头颈部肿瘤诱导化疗后口腔黏膜炎起到良好的预防和治疗作用,值得临床推广。Objective To explore the clinical efficacy of TanReQing injection in the prevention and treatment of chemo-therapy induced oral mucositis in head and neck neoplasm. Methods From January 2011 to April 2012, 120 patients who were firstly diagnosed with head and neck malignant tumor and were treated with chemotherapy in our hospital were randomly divided into control group, treatment group and prevention group, 40 cases in each group. Patients of the three groups were treated with 5-fluorouracil （5-Fu） plus cisplatin （PDD） scheme of induction chemotherapy. When patients in the control group and treatment group had oral mucositis after chemotherapy, they were treated with gargles of Saline plus gentamicin, dexamethasone, vitamin B6, three to five times per day, combined with symptomatic treatment by oral ulcer powder. But patients in treatment group got Tanreqing injection in addition. Patients in prevention group were treated as treatment group but they were treated by Tanre-qing injection at the beginning of chemotherapy. After treatment, three groups were compared in oral mucositis occurence rate, the time from the beginning of chemotherapy to the oral mucositis occurrence, the average healing time and the occurrence of adverse drug reactions. Results The oral mucositis occurrence rate in control group, treatment and prevention group were re-spectively 87.5%, 92.5%and 80%. There were no significant difference between the treatment group and the control group （P〉0.05）, while the oral mucositis occurrence rate in prevention group were significantly lower than that in the previous two groups （P〈0.05）. The occurrence rate of severe oral mucositis （Ⅲ~Ⅳ） in the control group, treatment and prevention group were 52.5%, 57.5%and 27.7% respectively;the rate had no significant difference between the treatment group and control group （P〉0.05）, but was significantly lower in the prevention group （P〈0.05）. The average time from the beginning of chemotherapy to the oral mucositis occurren

关 键 词：痰热清注射液 化疗 口腔黏膜炎 头颈部额肿瘤 预防治疗 

分 类 号：R730.6[医药卫生—肿瘤]