奥美拉唑联合奥曲肽与奥美拉唑单用治疗上消化道出血的疗效比较  

Comparison of the effect between octreotide combined with omeprazole and omeprazole alone in the treament of upper gastrointestinal bleeding

作　　者：杜坤庭[1] 葛勤利 万顺梅[1] 杨伟捷[1] 李斌[1] 杨玉捷[1] 

机构地区：[1]解放军第一医院消化科,甘肃省兰州730030

出　　处：《中国基层医药》2013年第4期528-530,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的比较奥美拉唑单独应用与联合奥曲肽治疗上消化道出血的临床疗效。方法回顾性分析101例上消化道出血患者的临床资料。根据治疗方法不同分为观察组（56例）和对照组（45例）。观察组采用奥曲肽联合奥美拉唑治疗，对照组仅用奥美拉唑治疗。对比分析两组治疗结果。结果观察组治疗总有效率为91．07％，高于对照组的73．33％（X^2=5．61，P〈0．05）；观察组平均止血时间为（15．9±3．9）h，明显短于对照组的（23．5±4．7）h（t=1．937，P〈0．05）；观察组治疗72h后的血红蛋白水平为（116．7±12．4）g／L，明显高于对照组的（91．5±17．3）g/L（t：2．013，P〈0．05）；观察组治疗后12h、24h、48h和72h的胃液pH值均高于对照组（均P〈0．05）。结论联合应用奥曲肽及奥美拉唑对上消化道出血的止血效果肯定，可明显缩短止血时间，提高治愈率。Objective To compare the effect of octreotide combined with omeprazole and omeprazole alone in the treament of upper gastrointestinal bleeding. Methods Clinical data of 101 patients with gastmintesinal bleed- ing were retrospectively analyzed. According to the treatment, the patients were divided into the observation group （56 cases） and control group（45 cases）. The patients in observation group were given octreotide and omeprazole, and pa- tients in control group were given omeprazol alone. Then the results of the two groups were analyzed. Results The total effective rate of observation group was 91.07% ,and was higher than that of the control group（73.33% ） （X2 = 5.61, P 〈 0.05 ） ; The average hemostasis time of observation group was （ 15.9±3.9 ） h, and was shorter than that ofthe control group [ （ 23.5±4.7 ） h ] （ t = 1. 937, P 〈 0.05 ） ; The hemoglobin level of the observation group was （ 116.7 ±12.4 ） g/h after 72 hours treatment, and was higher than that of the control group [ （91.5± 17.3 ） g/h ] （ t = 2. 013 ,P 〈 0.05） ;The pH of observation group was higher than that of control group after 12h,24h,48h and 72h treatment （ all P 〈 0.05 ）. Conclusion Octreotide combined with omeprazole is effective for upper gastrointesinal bleeding, and it can shorten the bleeding time and improve the cure rate.

关 键 词：上消化道出血 奥曲肽 奥美拉唑 

分 类 号：R573[医药卫生—消化系统]