裸鼠体内人类肿瘤杀伤细胞对自体恶性肿瘤杀伤作用的研究  

RESEARCHES ON THE ANTI-AUTOLOGOUS TUMOR EFFECTS OF HUMAN CANCER-KILLING CELLS IN NUDE MICE

作　　者：张滨学 唐尧 郑杰[1] 王洁良[1] 由江峰[1] 方伟岗[1] 殷澄[1] 吴秉铨[1] 王秀云[2] 高荣莲[2] 

机构地区：[1]北京医科大学病理学教研室 [2]北京医科大学第三医院妇产科

出　　处：《北京医科大学学报》1991年第6期432-434,共3页Journal of Peking University(Health Sciences)

基　　金：美国中华医学基金

摘　　要：本文利用卵巢癌手术标本建立体外细胞系及裸鼠移植瘤(OEC)。将来自同一病人的脾淋巴细胞体外经重组人类白细胞介素2活化为LAK细胞。裸鼠体内进行的Winn氏中和试验结果表明,L-AK细胞能有效地抑制自体恶性肿瘤在裸鼠体内的成瘤现象。Human Ovary Embryo Carcinoma (OEC) removed surgically have been transplanted into nude mi- ce and cultured in vitro, that would be used as targets. Lymphokine-activated killer cells were gener- ated from splenic lymphocytes of the OEC patient through co culturc with recombinant human inter- luekin-2 in vitro. The results of winn's test in nude mice have suggested that the LAK cells could effectively inhibit the growth of autologous tumors in vivo.

关 键 词：LAK细胞 肿瘤 白细胞介素2 

分 类 号：R730.3[医药卫生—肿瘤]