度洛西汀合并小剂量奥氮平对抑郁症患者的治疗作用  

A study of duloxetine plus low dose of olanzapine in the treatment with depression

作　　者：李学灵[1,2] 屈建新[1,2] 耿寒松[1,2] 张继涛[1,2] 王艳红[1,2] 刘艳江[1,2] 邹振民[1,2] 

机构地区：[1]河北省荣军医院,保定市071000 [2]河北联合大学附属医院

出　　处：《临床精神医学杂志》2013年第1期35-36,共2页Journal of Clinical Psychiatry

摘　　要：目的:探讨度洛西汀合并小剂量奥氮平治疗抑郁症的疗效。方法:采用随机双盲对照研究,将105例抑郁症患者随机分为研究组52例(度洛西汀合并小剂量奥氮平治疗),对照组53例(单用度洛西汀治疗);疗程8周。于治疗前及治疗后采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)及治疗中出现的症状量表(TESS)评定疗效及不良反应。结果:研究组和对照组显效率分别为94.0%和62.7%,以研究组疗效显著(t=2.37,P<0.05)。两组HAMD、HAMA治疗后各次评分均较治疗前显著下降(t=2.66～3.76,P均<0.01);以研究组降分显著(t=2.54～3.68,P<0.01或P<0.05)。两组不良反应相当(χ2=0.08,P>0.05)。结论:度洛西汀合并小剂量奥氮平治疗抑郁症疗效优于单一用药。Objective： To investigate the duloxetine plus low dose of olanzapine in the treatment of pa- tients with depression. Method：A randomized controlled study, 105 patients with depression were randomly divided into study group （52 cases with duloxetine plus small dose of olanzapine treatment） or in the control group （53 cases only with duloxetine treatment ） , the duration was 8 weeks. The efficacy and safety were as- sessed with Hamilton depression rating scale （HAMD） ,Hamilton anxiety scale （HAMA） and treatment emer- gent symptom scale （TESS） at baseline,1,2,4,6 and 8 weekend respectively. Results：The therapeutic effi- cacy in study group was significantly higher than that in control group, the improved rates were 94% and 62.7 % respectively after 8 weeks（ t = 2.37 ,P 〈 0.05 ）. The two groups showed score decreases on HAMD and HAMA after treatment （ t = 2.66 ~ 3.76, all P 〈 0.01 ） ; but in study group decreased more （ t = 2.54 ~ 3.68, P 〈 0. O1 or P 〈 0.05 ）. There was not an difference in TESS （X2 = 0.08, P 〉 0.05 ）. Conclusion ： Duloxetine plus low dose of olanzapine is more effective than single drug on depressive patients.

关 键 词：抑郁症 度洛西汀 奥氮平 

分 类 号：R749.4[医药卫生—神经病学与精神病学]