艾司西酞普兰与西酞普兰治疗抑郁症的随机、双盲对照研究  

A randomized double-blind study of escitalopram and citalopram in treating major depression

作　　者：吕振雷[1] 张云彪[1] 祁曙光[1] 

机构地区：[1]无锡市精神卫生中心普通精神科,214151

出　　处：《临床精神医学杂志》2013年第1期37-38,共2页Journal of Clinical Psychiatry

摘　　要：目的:观察艾司西酞普兰与西酞普兰治疗抑郁症的疗效及安全性。方法:将42例抑郁症患者随机分为艾司西酞普兰组20例(艾司西酞普兰治疗)和西酞普兰组22例(西酞普兰治疗),疗程6周。于治疗前及治疗l、2、4和6周分别采用17项汉密尔顿抑郁量表(HAMD)和治疗中出现的症状量表(TESS)评定疗效和不良反应。结果治疗6周,艾司西酞普兰组和西酞普兰组的HAMD总分分别从治疗前(23.06±2.22)分和(22.78±2.03)分降至(7.76±2.98)分和(7.90±3.11)分;两组有效率分别为80.0%和77.3%(χ2=0.046,P=0.830),痊愈率分别为50.0%和45.5%(χ2=1.828,P=0.176)。两组间不良反应差异无统计学意义(P>0.05)。结论:艾司西酞普兰与西酞普兰抗抑郁疗效相同,但艾司西酞普兰起效更快。Objective： To evaluate the efficacy and safety of escitalopram for depressive patients. Method ： Forty-two depressive patients were randomized into eseitalopram group （ n = 20） and citalopram group （ n = 22） for a 6 weeks double-blind study. 17 items HAMD and treatment emergent symptoms scale were used to assess the effectiveness and safety before treatment and by the end of 1,2,4, and 6 weeks. Results： After 6 weeks of treatment, the HAMD scores decreased from （ 23.06 ± 2.22 ） and （ 22.78 ± 2.03 ） to （ 7.76 ：l： 2.98 ） and （7.90 ±3.11 ） in the escitalopram group and the citalopram group respectively, the effective rate was 80.0% and 77.3% , and the curative rate was 50.0% and 45.5%. There was no significant difference in the effective and curative rate between the 2 groups （ X2 = 0. 046 ,P = 0.830 ; X2 = 1. 828 ,P = 0. 176）. No significant differ- ence was found in main side effects between the 2 groups （ P 〉 0.05 ）. Conclusion ： Escitalopram and citalo- pram are similarly effective and safe in the treatment of depression, but escitalopram has earlier response.

关 键 词：抑郁症 艾司西酞普兰 西酞普兰 

分 类 号：R749.4[医药卫生—神经病学与精神病学]