意外胆囊癌组织层粘连蛋白受体的表达与肿瘤转移的关系研究  

Expression of laminin receptor and its relation to metastasis in patients with unexpected gallbladder carcinoma

作　　者：宋政炜[1] 倪全法[1] 蒋达峰[1] 费建国[1] 秦红波[1] 

机构地区：[1]嘉兴学院附属第二医院肝胆外科,314000

出　　处：《浙江医学》2013年第2期108-110,共3页Zhejiang Medical Journal

摘　　要：目的探讨意外胆囊癌组织层粘连蛋白受体（LN—R）表达与肿瘤组织学类型、分化程度、临床分期及转移的关系。方法对49例意外胆囊癌患者的临床资料进行回顾性分析，采用免疫组织化学法（EnVision二步法）对胆囊癌组织进行LN—R的检测。结果LN—R的阳性表达率为71．4％（35／49），LN—R的阳性表达与肿瘤临床分期密切相关；592％（29／49）的患者术后发现肿瘤转移；LN—R阳性组及LN—R阴性组肿瘤转移率分别为686％（24／35）及357％（5／14），两组比较差异有统计学意义（P〈0，05）。结论意外胆囊癌组织LN—R的表达与否与肿瘤临床分期及转移率有关，LN—R的阳性表达提示转移可能性大，需严格把握再次根治手术指征。Objective To investigate the expression of laminin receptor （LN-R） and its relation to clinicopathological fea- tures of unexpected gallbladder carcinoma （UCG）, Methods The expression of LN-R was detected by immunohistochemical assay in 49 patients with UCG; its relation to clinicopathological features of UCG patients was analyzed. Results The positive rate of LN-R expression was 71.4% in 49 cases. The expression of LN-R was correlated with the clinical stage of carcinoma. The metastasis rate of UGC accounted for 59.2% （29/49） after surgery; 68.6% （24/35） patients with LN-R expression had metas- tasis compared to 35.7% （5/14） in those without LN-R expression （P〈0.05）. Conclusion The expression of LN-R may predict postoperative metastasis in patients with UCG and suggests the necessity of secondary radical resection.

关 键 词：意外胆囊癌肿瘤转移层粘连蛋白受体 

分 类 号：R735.7[医药卫生—肿瘤]