负载无机和有机防晒剂纳米结构脂质载体(NLC)的制备和表征  

Preparation and characteration of organic and inorganic sunscreens loaded nanostructured lipid carriers (NLC)

作　　者：陈衍玲[1,2] 夏强[1,2,3] 

机构地区：[1]东南大学生物科学与医学工程学院,江苏南京210096 [2]东南大学苏州市生物医用材料与技术重点实验室,江苏苏州215123 [3]苏州纳康生物科技有限公司,江苏苏州215123

出　　处：《日用化学品科学》2013年第2期25-27,32,共4页Detergent & Cosmetics

基　　金：国际科技合作项目(2008DFB50060)

摘　　要：运用高压均质法制备负载乙基己基三嗪酮(Ethylhexyl triazone,Uvinul T 150)和氧化锌(Zinc oxide,ZnO)的纳米结构脂质载体(NLC),利用光子相关光谱(PCS)测得在常温下的平均粒径为314 nm±4 nm,多分散指数(PD)I在0.10～0.30;利用pH计测得样品的pH接近于7.0;用反相高效液相色谱法(RP-HPLC)测得复合防晒剂-NLC中Uvinul T 150的保留率在8.98 g/mL～9.76 g/mL之间。最后,从温度和时间稳定性考察得到,新型复合防晒剂-NLC具有良好的稳定性。Ethylhexyl triazone （Uvinul T 150） and zinc oxide loaded nanostructured lipid carried were prepared by High Press Homogenization （HPH）. At room temperature, the average particle sizes measured by Photon Correlation Spectroscopy （PCS） were in the range of 314 nm ± 4 nm, and the polydispersity index （PDI） were from 0.100 to 0.300. The pH of sunscreen formulation near to 7.00 was closed to the pH of man＇ s skin. The reservation of Uvinul T 150 of sunscreen formulation was in the range of 8.98 g / mL to 9.76 g / mL by RP-HPLC. The stability of storage time and temperature on the physicochemical properties of sunscreen formulation were investigated in details.

关 键 词：乙基己基三嗪酮 氧化锌 纳米结构脂质载体 保留率 稳定性 

分 类 号：TQ658.2[化学工程—精细化工]