中国东北地区汉族癫痫患者HLA-B*1502等位基因分布频率  

Distributed frequency of the allele HLA-B*1502 in Han ethnic epilepsy patients living in northeastern region of China

作　　者：何晓静[1] 汝继玲[1] 肇丽梅[1] 

机构地区：[1]中国医科大学附属盛京医院药学部,沈阳110004

出　　处：《中国临床药理学杂志》2013年第2期98-99,103,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(30973597;81102517)

摘　　要：目的研究中国东北地区汉族癫痫患者HLA-B*1502等位基因分布的频率。方法用聚合酶链反应DNA序列分析法,对125例中国东北地区汉族癫痫患者DNA标本进行HLA-B基因分型。结果 125例DNA标本中,共检测出34种不同的HLA-B等位基因。其中,2例患者携带HLA-B*1502等位基因。HLA-B*1502等位基因在中国东北地区癫痫患者中的分布频率为1.6%。其他分布频率较高的等位基因分别为HLA-B*4001、B*4601、B*4801、B*1302和B*4002。结论东北地区癫痫患者中HLA-B*1502等位基因分布频率(1.6%)与其在北京地区健康汉族人群中的分布频率近似(1.5%);但远低于其在中国中部、西部及南部地区的分布频率。Objective To study the distributed frequency of the allele of HLA - B ＊ 1502 in Han ethnic epilepsy patients living in northeastern region of China. Methods The polymerase chain reaction sequence - based typing method was used to detect the genotype of HLA - B ＊ 1502 of all 125 epilepsy patients. Results Among all 125 epilepsy patients, there are 34 different types of alleles and only 2 patients with positive HLA - B ＊ 1502. The distributed frequency of the allele of HLA - B ＊ 1502 in Han ethnic epilepsy patients living in northeastern region of China is 1.6 %. The other main alleles with high distributed frequencies are HLA - B ＊ 4001, B ＊ 4601, B ＊ 4801, B ＊ 1302and B ＊ 4002, respectively. Conclusion The distributed frequency of HLA - B ＊ 1502 of Han ethnic epilepsy patients living in northeastern region of China is very similar to that in Beijing, which is far lower than that in central, western and southern regions of China.

关 键 词：HLA-B＊1502 分布频率 汉族癫痫患者 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R394.5[医药卫生—临床医学]