残胃黏膜病变与幽门螺杆菌感染的关系  

Research of the relationship between Helicobacter pylori infections and remnant

作　　者：尹曙明[1] 黄一沁[1] 项平[1] 肖立[1] 张赣生[1] 陈洁[1] 保志军[1] 于晓峰[1] 

机构地区：[1]复旦大学附属华东医院消化内科,上海200040

出　　处：《临床内科杂志》2013年第1期48-51,共4页Journal of Clinical Internal Medicine

摘　　要：目的研究幽门螺杆菌（Hp）感染与残胃黏膜病变的关系。方法选取胃大部切除术后的残胃患者58例为残胃1组（良性消化性溃疡术后），83例为残胃2组（早期胃癌术后），分别进行胃镜、病理组织学及Hp检测。结果残胃1组患者胃黏膜炎症（P〉0．05）、活动性（P〈0．05）和Hp感染发生率（P〈0．05）等均高于残胃2组。两组Hp感染者慢性萎缩性胃炎、癌前病变及活动性等均高于未感染者（P〈0．05），而未感染者在残胃2组中的慢性非萎缩性胃炎较感染者更多见（P〈0．05）。残胃2组Hp检出率随着胃黏膜病变程度的加重而出现降低趋势（P〉0．05），且癌前病变与Hp感染有相关性（P〈0．05）。结论术后残胃黏膜病变与Hp感染密切相关。Objective To analysis the relationship between Helicobacter pylori （Hp）infections and remnant mueosal lesions following partial gastrectomy. Methods Gastric stump after partial gastrec- tomy with benign peptic ulcer（ group 1, n = 58 ） and early gastric cancer after operation （ group 2, n = 83 ） were recuited in this prospective study. All patients underwent examinations including upper digestive en- doscopy,pathologic histology and Hp infection for the remnant mucosal lesions. Results The incidence rate of inflammation（ P 〉 0.05 ）, activity（ P 〈 0.05 ） and Hp infection（ P 〈 0.05 ） in the groupl was high- er than that in the group 2 （ P 〈 0.05 ）. In these 2 groups, Hp-positive cases had a higher incidence rate of chronic atrophic gastritis, precancerous lesion and activity than Hp-negative cases （ P 〈 0.05 ）. Whereas Hp-negative cases showed a higher incidence rate of chronic nonatrophic gastritis（ P 〈 0.05 ）. There was a negative correlation between the grade of gastric mucosal lesions and Hp positive detection rate （P 〉 0.05 ）. Precancerous lesion were significantly correlated with Hp infection （P 〈 0.05 ）. Conclusion The remnant mucosal lesions following partial gastrectomy were closely correlated with Hp infection.

关 键 词：残胃 胃切除术 病理 幽门螺杆菌 

分 类 号：R735.2[医药卫生—肿瘤]