64层灌注CT评价兔VX_2体部肿瘤模型氧分压的实验研究  

Using the 64-slice Perfusion CT to Evaluate the Oxygen Tension (pO_2) in the Rabbit VX_2 Tumor Model:An Experimental Study

作　　者：孙昌进[1] 王光辉[1] 李超[1] 李涛[1] 罗云秀[1] 吕海波[2] 张德康[1] 李彦[1] 黄建鸣[1] 肖明勇[1] 阴俊[1] 于金明[3] 郎锦义[1] 

机构地区：[1]四川省肿瘤医院,成都610041 [2]成都市第一人民医院,成都610041 [3]山东省肿瘤医院,济南250000

出　　处：《肿瘤预防与治疗》2013年第1期7-11,共5页Journal of Cancer Control And Treatment

基　　金：国家自然基金资助(项目号:c03031802);四川省青年基金(项目号:09ZQ026-065)

摘　　要：目的:利用64层灌注CT评价兔VX_2肿瘤模型氧分压并与氧微电极法对照。方法:对45只成功建模兔VX_2脑瘤模型行灌注CT检查。测量脑瘤兴趣区灌注值(perfusion)、血容量(blood volume,BV)、达峰时间(time to peak TTP)、最大峰值(peak enhancement intensity,PEI)。结果与该兴趣区氧微电极法测得氧分压(PO_2)对照。结果:45例成功建模兔VX2脑瘤兴趣区灌注值范围为1.3 ml/min～127.0 ml/min,平均为27.102 ml/min±26.723 ml/min;BV为1.2 ml/100g～53.1ml/100g,平均为22.196 ml/100g±13.680ml/100g,PEI为8.7 HU～124.6HU,平均为43.456 HU±28.73 HU;TTP为8.2 sec～62.5 sec,平均为38.823 sec±14.759 sec;对应区域PO_2为0.14 mmHg～46.70mmHg,平均为15.981 mmHg±14.815mmHg。灌注值与对应区域PO_2相关系数为0.673,有统计学意义(P=0.00)。BV、PEI、TTP与与对应区域PO_2相关系数分别为0.271、0.253、-0.18,均无统计学意义(P=0.071,P=0.094,P=0.237)。结论:64层灌注CT有预测肿瘤氧分压的能力。Objective： To investigate the role of the 64-slice perfusion CT in the evaluation of the oxygen tension （ pO2 ） in the rabbit VX2 tumor model. Methods： Forty-five rabbit VX2 brain tumor model established successfully were examined with 64-detector row CT. Tumor specimens were assessed for the oxygen tension （pO2 ） , perfusion, blood volume （BV）, peak enhancement intensity（PEI） and time to peak （TIP）, and Pearson correlation coefficients were conducted to represent the relationships between the perfusion parame- ters and pO2 of the tumor, pO2was measured by oxygen-sensitive electrodes guided by perfusion CT images. Results： Mean values for perfusion,BV,PEI, TFP and pO2 of the 45 tumors were 27. 102 ± 26. 723ml/min, 22. 1 96 ±13.680ml/100g,43.456 ±28.73 HU, 38. 823 ± 14. 759 sec, and 15. 981 ±14. 815mmHg, respectively. BV, PEI, TIP were not significant correlated with pO2 （ r = 0. 271, 0. 253, -0. 18, P 〉 0. 05 ）, whereas positively correlation was found between perfusion with pO2 （r = 0. 673, P = 0. 00 ）. Conclusion： The perfusion value from 64-slice spiral CT perfusion imaging might to have ability to evaluate the tumor pO2

关 键 词：体层摄影术 X线计算机 灌流 肿瘤 放射疗法 氧分压 

分 类 号：R73-36[医药卫生—肿瘤]